模块化蛋白质构建块作为传感、传递和治疗剂的生物组装。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Emily A Berckman, Emily J Hartzell, Alexander A Mitkas, Qing Sun, Wilfred Chen
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引用次数: 16

摘要

大自然已经进化出一系列的策略来创造自组装的蛋白质纳米结构,这些结构具有结构定义的结构,服务于无数高度专业化的生物功能。随着用于位点特异性蛋白质修饰和从头蛋白质设计的生物工具的出现,使用天然和合成生物构建块来模仿这些靶向生物医学应用的天然设计,已经创建了广泛的定制蛋白质纳米载体。本文综述了实现这些功能性蛋白质纳米结构的不同设计框架和合成修饰策略。讨论了这些设计蛋白纳米结构的关键属性、独特功能及其对生物传感和治疗应用的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological Assembly of Modular Protein Building Blocks as Sensing, Delivery, and Therapeutic Agents.

Nature has evolved a wide range of strategies to create self-assembled protein nanostructures with structurally defined architectures that serve a myriad of highly specialized biological functions. With the advent of biological tools for site-specific protein modifications and de novo protein design, a wide range of customized protein nanocarriers have been created using both natural and synthetic biological building blocks to mimic these native designs for targeted biomedical applications. In this review, different design frameworks and synthetic decoration strategies for achieving these functional protein nanostructures are summarized. Key attributes of these designer protein nanostructures, their unique functions, and their impact on biosensing and therapeutic applications are discussed.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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