恩贾梅纳(乍得)的抗菌素耐药性:法国前沿医疗和外科小组参与"巴克哈内手术"的四年经验

IF 5 Q3 Medicine
M. Cardinale , F. Bourbotte-Salmon , C. Scheiwe , S. Boulezaz , M. Ridet , P. Laitselart
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引用次数: 1

摘要

目的了解局部抗菌素耐药性(AMR)模式是有效治疗细菌性疾病的必要条件。目前对非洲地区,特别是萨赫勒地区常见致病菌的耐药模式知之甚少。我们的目的是描述当地的细菌流行病学,并确定法国建议的经验性治疗是否可以实施。患者和方法我们进行了一项单中心观察性研究。回顾性收集2015年1月至2018年12月前沿医学外科中心(FFMSC)细菌数据库中的数据。所有细菌分析,阴性或阳性,包括在内。结果共分析样品2194份。感染性疾病为尿路感染(20.8%)、骨和关节感染(20.4%)、慢性伤口皮肤感染(13.4%)、软组织脓肿(13%)和肠胃炎(10.8%)。最常见的感染是肠杆菌感染(43.6%)和葡萄球菌感染(31.1%)。AMR患病率为32.1%。在恩贾梅纳,乍得人群中发现的产esbl细菌(41.3%)明显多于法国人群(6.3%)(P <0.001)。结论我们报道了恩贾梅纳地区产esbl细菌的高发率。因此,在FFMSC中使用经经性抗生素治疗可能会受到质疑:法国的建议不能在这种情况下实施,应考虑使用碳青霉烯类或新的抗esbl抗生素。需要前瞻性研究来得出结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antimicrobial resistance in N’Djamena (Chad): Four-year experience of the French Forward Medical and Surgical Team engaged in the “Barkhane Operation”

Objectives

Knowledge of local antimicrobial resistance (AMR) patterns is required for effective empirical treatment of bacterial diseases. Very little is known about current resistance patterns of common pathogenic bacteria in the African region and particularly in the Sahel region. We aimed to describe the local bacterial epidemiology and to determine whether French recommendations for empirical treatment could be implemented.

Patients and methods

We performed a single-center observational study. Data was collected retrospectively from the Forward Medical and Surgical Center (FFMSC) bacterial database from January 2015 to December 2018. All bacteriological analyses, negative or positive, were included.

Results

A total of 2194 samples were analyzed. Infectious diseases were urinary tract infections (20.8%), bone and joint infections (20.4%), skin infections of chronic wounds (13.4%), soft tissue abscesses (13%), and gastroenteritis (10.8%). The most frequent infections were enterobacterial infections (43.6%) and staphylococcal infections (31.1%). The prevalence of AMR was 32.1%. Significantly more ESBL-producing bacteria (41.3%) were observed in the Chadian population than in the French population in N’djamena (6.3%) (P < 0.001).

Conclusions

We reported a high rate of ESBL-producing bacteria in N’Djamena. The use of empirical antibiotic therapies in the FFMSC may thus be questioned: French recommendations cannot be implemented in such setting and the use of carbapenems or new anti-ESBL antibiotics should be considered. Prospective studies are required to conclude.

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来源期刊
Medecine et maladies infectieuses
Medecine et maladies infectieuses 医学-传染病学
CiteScore
1.10
自引率
0.00%
发文量
0
审稿时长
10.7 weeks
期刊介绍: L''organe d''expression de la Société de Pathologie Infectieuse de Langue Française (SPILF). Médecine et Maladies Infectieuses is the official publication of the Société de Pathologie Infectieuse de Langue Française (SPILF). Médecine et Maladies Infectieuses is indexed in the major databases: Medline, Web of Science/Clarivate and Scopus. The journal publishes scientific /research articles, general reviews, short communications and letters, in both English and French. The journal welcomes submissions on the various aspects of infectious pathologies and pathogenic agents. Médecine et Maladies Infectieuses focuses on clinical therapeutics, nosocomial infections, biology, prevention, as well as epidemiology and therapeutics.
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