D-丝氨酸在重复经颅磁刺激对中风后患者的益处中的作用。

IF 2.6 4区 医学 Q3 NEUROSCIENCES
Masachika Niimi, Yuko Fujita, Tamaki Ishima, Kenji Hashimoto, Nobuyuki Sasaki, Takatoshi Hara, Naoki Yamada, Masahiro Abo
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引用次数: 0

摘要

目的:通过 N-甲基-D-天冬氨酸受体(NMDAR)进行的神经传递异常在神经精神疾病的病理生理学中发挥着作用。重复经颅磁刺激(rTMS)对 NMDAR 相关氨基酸的影响尚不清楚。我们旨在研究经颅磁刺激对脑卒中后患者血清中 NMDAR 相关氨基酸的影响:方法:我们连续招募了 95 名上肢偏瘫的脑卒中后患者。27名患者的贝克抑郁量表(BDI)得分在10分以上。12名抑郁症患者接受了经颅磁刺激联合康复治疗,15名非抑郁症患者只接受了为期14天的康复治疗,未接受经颅磁刺激治疗。1赫兹经颅磁刺激应用于非病变半球的初级运动区。治疗前后均进行了 BDI 测试。治疗前后测量了血清谷氨酰胺、谷氨酸、甘氨酸、L-丝氨酸和D-丝氨酸水平:结果:抑郁症患者与非抑郁症患者在临床特征、血清中五种氨基酸的水平和氨基酸比例方面没有差异。然而,在 27 名抑郁症患者中,血清中谷氨酸的水平与 BDI 存在显著相关性(ρ=0.428,p=0.026)。抑郁症患者在接受或不接受经颅磁刺激治疗后,BDI均明显下降。经颅磁刺激康复治疗组的D-丝氨酸减少,而不经颅磁刺激康复治疗组的D-丝氨酸增加。L-丝氨酸在经颅磁刺激康复治疗组中增加,但在未接受经颅磁刺激康复治疗组中减少:结果表明,经颅磁刺激可以调节血液中与 NMDAR 相关的氨基酸,产生有益的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of D-serine in the beneficial effects of repetitive transcranial magnetic stimulation in post-stroke patients.

Objective: Abnormalities in neurotransmission via N-methyl-D-aspartic acid receptor (NMDAR) play a role in the pathophysiology of neuropsychiatric disorders. The impact of repetitive transcranial magnetic stimulation (rTMS) on NMDAR-related amino acids remains unknown. We aim to investigate the effects of rTMS on NMDAR-related amino acids in serum of post-stroke patients.

Methods: Ninety-five consecutive post-stroke patients with upper limb hemiparesis were recruited. In 27 patients, the Beck Depression Inventory (BDI) score was 10 or higher. Twelve depressed patients underwent rehabilitation in combination with rTMS and 15 non-depressed patients underwent rehabilitation only without rTMS for 14 days. 1 Hz rTMS was applied to the primary motor area in the non-lesional hemisphere. BDI was conducted before and after treatment. Serum glutamine, glutamate, glycine, L-serine, and D-serine levels were measured before and after treatment.

Results: There were no differences between depressed patients and non-depressed patients in clinical characteristics, levels of the five amino acids in serum, and the ratio of amino acids. However, in 27 depressed patients there was a significant correlation between levels of glutamate in serum and BDI (ρ=0.428、p=0.026). BDI decreased significantly in depressed patients after treatment with or without rTMS. D-serine decreased in the rehabilitation with rTMS group, but increased in the rehabilitation without rTMS group. L-serine increased in the rehabilitation with rTMS group, but decreased in the rehabilitation without rTMS group.

Conclusions: The results suggest that rTMS can modulate NMDAR-related amino acids in blood, producing beneficial effects.

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来源期刊
Acta Neuropsychiatrica
Acta Neuropsychiatrica NEUROSCIENCES-PSYCHIATRY
自引率
5.30%
发文量
30
期刊介绍: Acta Neuropsychiatrica is an international journal focussing on translational neuropsychiatry. It publishes high-quality original research papers and reviews. The Journal''s scope specifically highlights the pathway from discovery to clinical applications, healthcare and global health that can be viewed broadly as the spectrum of work that marks the pathway from discovery to global health.
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