MUC家族成员在结直肠癌中的预后和临床病理意义:系统回顾和荟萃分析。

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Gastroenterology Research and Practice Pub Date : 2019-12-20 eCollection Date: 2019-01-01 DOI:10.1155/2019/2391670
Chao Li, Didi Zuo, Tao Liu, Libin Yin, Chenyao Li, Lei Wang
{"title":"MUC家族成员在结直肠癌中的预后和临床病理意义:系统回顾和荟萃分析。","authors":"Chao Li,&nbsp;Didi Zuo,&nbsp;Tao Liu,&nbsp;Libin Yin,&nbsp;Chenyao Li,&nbsp;Lei Wang","doi":"10.1155/2019/2391670","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics.</p><p><strong>Methods: </strong>The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used to evaluate associations between MUC expression levels and prognosis or clinicopathological characteristics, respectively. The heterogeneity between studies was assessed by the <i>I</i> <sup>2</sup> values, whereas the likelihood of publication bias was assessed by Egger's linear regression and Begg's rank correlation test.</p><p><strong>Results: </strong>Among 33 included studies (<i>n</i> = 6032 patients), there were no associations between combined MUC phenotype expression levels and overall survival (OS) or disease-free survival (DFS)/relapse-free survival (RFS) in patients with CRC. In subgroup analyses, the upregulated MUC1 expression (HR = 1.50; 95% CI, 1.29-1.74; <i>P</i> < 0.00001) was associated with poor OS. However, the upregulated MUC2 expression (HR = 0.64; 95% CI, 0.52-0.79; <i>P</i> < 0.00001) was associated with better OS. Furthermore, a high level of MUC1 expression (HR = 1.99; 95% CI, 0.99-3.99; <i>P</i> = 0.05) was associated with shorter DFS/RFS. However, patients with a low level of MUC2 tumors showed better DFS/RFS than patients with a high level of MUC2 tumors (HR = 0.71; 95% CI, 0.49-1.04; <i>P</i> = 0.08; <i>P</i> = 0.0.009, <i>I</i> <sup>2</sup> = 67%) and MUC5AC expression (HR = 0.56; 95% CI, 0.38-0.82; <i>P</i> = 0.003) was associated with longer DFS/RFS. In addition, a high level of MUC1 expression was associated with CRC in the rectum, deeper invasion, lymph node metastasis, distant metastasis, advanced tumor stage, and lymphatic invasion. A high level of MUC2 expression had a protective effect. High secretion of MUC5AC is associated with colon cancer compared with rectal cancer.</p><p><strong>Conclusion: </strong>The protein expression of MUC1 might be a poor biomarker in colorectal cancer and might play a role in tumor transformation and metastasis. However, the protein expression of MUC2 expression might have a protective effect. Furthermore, randomized controlled trials (RCTs) of large patients are needed to confirm the results.</p>","PeriodicalId":12597,"journal":{"name":"Gastroenterology Research and Practice","volume":"2019 ","pages":"2391670"},"PeriodicalIF":2.0000,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/2391670","citationCount":"19","resultStr":"{\"title\":\"Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.\",\"authors\":\"Chao Li,&nbsp;Didi Zuo,&nbsp;Tao Liu,&nbsp;Libin Yin,&nbsp;Chenyao Li,&nbsp;Lei Wang\",\"doi\":\"10.1155/2019/2391670\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics.</p><p><strong>Methods: </strong>The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used to evaluate associations between MUC expression levels and prognosis or clinicopathological characteristics, respectively. The heterogeneity between studies was assessed by the <i>I</i> <sup>2</sup> values, whereas the likelihood of publication bias was assessed by Egger's linear regression and Begg's rank correlation test.</p><p><strong>Results: </strong>Among 33 included studies (<i>n</i> = 6032 patients), there were no associations between combined MUC phenotype expression levels and overall survival (OS) or disease-free survival (DFS)/relapse-free survival (RFS) in patients with CRC. In subgroup analyses, the upregulated MUC1 expression (HR = 1.50; 95% CI, 1.29-1.74; <i>P</i> < 0.00001) was associated with poor OS. However, the upregulated MUC2 expression (HR = 0.64; 95% CI, 0.52-0.79; <i>P</i> < 0.00001) was associated with better OS. Furthermore, a high level of MUC1 expression (HR = 1.99; 95% CI, 0.99-3.99; <i>P</i> = 0.05) was associated with shorter DFS/RFS. However, patients with a low level of MUC2 tumors showed better DFS/RFS than patients with a high level of MUC2 tumors (HR = 0.71; 95% CI, 0.49-1.04; <i>P</i> = 0.08; <i>P</i> = 0.0.009, <i>I</i> <sup>2</sup> = 67%) and MUC5AC expression (HR = 0.56; 95% CI, 0.38-0.82; <i>P</i> = 0.003) was associated with longer DFS/RFS. In addition, a high level of MUC1 expression was associated with CRC in the rectum, deeper invasion, lymph node metastasis, distant metastasis, advanced tumor stage, and lymphatic invasion. A high level of MUC2 expression had a protective effect. High secretion of MUC5AC is associated with colon cancer compared with rectal cancer.</p><p><strong>Conclusion: </strong>The protein expression of MUC1 might be a poor biomarker in colorectal cancer and might play a role in tumor transformation and metastasis. However, the protein expression of MUC2 expression might have a protective effect. Furthermore, randomized controlled trials (RCTs) of large patients are needed to confirm the results.</p>\",\"PeriodicalId\":12597,\"journal\":{\"name\":\"Gastroenterology Research and Practice\",\"volume\":\"2019 \",\"pages\":\"2391670\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2019-12-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1155/2019/2391670\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterology Research and Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2019/2391670\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology Research and Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2019/2391670","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 19

摘要

目的:探讨结直肠癌(CRC)组织中MUC表达水平与预后的关系,探讨MUC表达水平与CRC临床病理特征的关系。方法:检索PubMed, Embase, Cochrane Library和Web of Science数据库,从成立到2019年9月13日,以确定研究CRC组织中MUC表达水平与预后之间关系的研究。分别采用合并风险比(hr)或优势比(ORs)和95%可信区间(CIs)来评估MUC表达水平与预后或临床病理特征之间的关系。研究间异质性采用i2值评估,发表偏倚可能性采用Egger’s线性回归和Begg’s秩相关检验评估。结果:在33项纳入的研究中(n = 6032例患者),MUC联合表型表达水平与结直肠癌患者的总生存期(OS)或无病生存期(DFS)/无复发生存期(RFS)之间没有相关性。在亚组分析中,MUC1表达上调(HR = 1.50;95% ci, 1.29-1.74;P < 0.00001)与不良OS相关。然而,MUC2表达上调(HR = 0.64;95% ci, 0.52-0.79;P < 0.00001)与较好的OS相关。此外,MUC1高水平表达(HR = 1.99;95% ci, 0.99-3.99;P = 0.05)与较短的DFS/RFS相关。然而,MUC2低水平肿瘤患者的DFS/RFS优于MUC2高水平肿瘤患者(HR = 0.71;95% ci, 0.49-1.04;P = 0.08;P = 0.0.009, i2 = 67%)和MUC5AC表达(HR = 0.56;95% ci, 0.38-0.82;P = 0.003)与较长的DFS/RFS相关。此外,MUC1的高水平表达与直肠结直肠癌、深部浸润、淋巴结转移、远处转移、肿瘤晚期和淋巴浸润相关。MUC2高水平表达具有保护作用。与直肠癌相比,MUC5AC的高分泌与结肠癌相关。结论:MUC1蛋白在结直肠癌中的表达可能是一个较差的生物标志物,可能在肿瘤转化和转移中发挥作用。然而,蛋白表达MUC2的表达可能具有保护作用。此外,需要对大型患者进行随机对照试验(rct)来证实结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.

Prognostic and Clinicopathological Significance of MUC Family Members in Colorectal Cancer: A Systematic Review and Meta-Analysis.

Objective: To assess the association between MUC expression levels in colorectal cancer (CRC) tissues and prognosis and investigate the associations between MUC expression levels and CRC clinicopathological characteristics.

Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched from inception through September 13, 2019, to identify studies investigating the association between MUC expression levels in CRC tissues and prognosis. Pooled hazard ratios (HRs) or odds ratio (ORs) with 95% confidence intervals (CIs) were used to evaluate associations between MUC expression levels and prognosis or clinicopathological characteristics, respectively. The heterogeneity between studies was assessed by the I 2 values, whereas the likelihood of publication bias was assessed by Egger's linear regression and Begg's rank correlation test.

Results: Among 33 included studies (n = 6032 patients), there were no associations between combined MUC phenotype expression levels and overall survival (OS) or disease-free survival (DFS)/relapse-free survival (RFS) in patients with CRC. In subgroup analyses, the upregulated MUC1 expression (HR = 1.50; 95% CI, 1.29-1.74; P < 0.00001) was associated with poor OS. However, the upregulated MUC2 expression (HR = 0.64; 95% CI, 0.52-0.79; P < 0.00001) was associated with better OS. Furthermore, a high level of MUC1 expression (HR = 1.99; 95% CI, 0.99-3.99; P = 0.05) was associated with shorter DFS/RFS. However, patients with a low level of MUC2 tumors showed better DFS/RFS than patients with a high level of MUC2 tumors (HR = 0.71; 95% CI, 0.49-1.04; P = 0.08; P = 0.0.009, I 2 = 67%) and MUC5AC expression (HR = 0.56; 95% CI, 0.38-0.82; P = 0.003) was associated with longer DFS/RFS. In addition, a high level of MUC1 expression was associated with CRC in the rectum, deeper invasion, lymph node metastasis, distant metastasis, advanced tumor stage, and lymphatic invasion. A high level of MUC2 expression had a protective effect. High secretion of MUC5AC is associated with colon cancer compared with rectal cancer.

Conclusion: The protein expression of MUC1 might be a poor biomarker in colorectal cancer and might play a role in tumor transformation and metastasis. However, the protein expression of MUC2 expression might have a protective effect. Furthermore, randomized controlled trials (RCTs) of large patients are needed to confirm the results.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Gastroenterology Research and Practice
Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.40
自引率
0.00%
发文量
91
审稿时长
1 months
期刊介绍: Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信