DRD2/ANKK1 Taq1A基因型与店内零售食品环境暴露对魁北克成人饮食质量的相互作用

IF 2 4区 医学 Q3 GENETICS & HEREDITY
Lifestyle Genomics Pub Date : 2020-01-01 Epub Date: 2019-12-18 DOI:10.1159/000504603
Daiva E Nielsen, Yang Han, Catherine Paquet, Andre K Portella, Yu Ma, Laurette Dube
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引用次数: 5

摘要

背景/目的:基因-环境相互作用可能与营养结果有关。本研究评估了DRD2/ANKK1 Taq1A基因型与店内零售食品环境暴露对饮食质量的相互作用。方法:CARTaGENE生物银行数据(n = 3532)与省级食品零售数据相关联。加拿大2010年健康饮食指数(HEI-C)是根据食物频率问卷计算得出的。采用调整了社会人口因素、人体测量学和能量摄入的广义线性模型来评估Taq1A变异与零售食品测量之间的相互作用。结果:Taq1A和冰淇淋店陈列对HEI-C评分之间存在显著的负交互作用(估计:-15.46[95%可信区间(CI): -24.83, -6.10], p = 0.0012),其中,在等位基因携带者中,与低暴露的等位基因携带者相比,增加对冰淇淋陈列的暴露与较低的HEI-C评分相关。Taq1A与蔬菜价格之间还观察到显著的正交互作用,其中,在等位基因携带者中,与暴露于较低价格的等位基因携带者相比,暴露于较高价格的等位基因携带者与较高的HEI-C评分相关(估计:2.46 [95% CI: 0.78, 4.14], p = 0.0041)。在非携带者中观察到相反的模式。结论:DRD2/ANKK1 Taq1A与对冰淇淋陈列和蔬菜价格的适应性反应有关,表明对零售环境食物线索的不同敏感性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interaction of DRD2/ANKK1 Taq1A Genotype with in-Store Retail Food Environment Exposures on Diet Quality in a Cohort of Quebec Adults.

Background/aims: Gene-environment interactions may be relevant for nutrition outcomes. This study assessed the interaction between DRD2/ANKK1 Taq1A genotype and exposures to in-store retail food environment on diet quality.

Methods: CARTaGENE biobank data (n = 3,532) were linked to provincial food retail data. The Canadian adaptation of the Healthy Eating Index 2010 (HEI-C) was calculated from food frequency questionnaires. Generalized linear models adjusted for sociodemographic factors, anthropometrics, and energy intake were used to assess interactions between the Taq1A variant and retail food measures.

Results: A significant inverse interaction was observed between Taq1A and ice cream store displays on HEI-C score (estimate: -15.46 [95% confidence interval (CI): -24.83, -6.10], p = 0.0012) where, among allele carriers, increasing exposure to ice cream displays was associated with a lower HEI-C score as compared to allele carriers with a lower exposure. A significant positive interaction between Taq1A and price of vegetables was also observed, where, among allele carriers, increasing exposure to a higher price was associated with a higher HEI-C score compared to allele carriers with exposure to a lower price (estimate: 2.46 [95% CI: 0.78, 4.14], p = 0.0041). The opposite pattern was observed among non-carriers.

Conclusions: DRD2/ANKK1 Taq1A is associated with adaptive responses to ice cream displays and vegetable prices, suggesting a differential susceptibility to retail environment food cues.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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