用七氟醚和美托咪定麻醉的纯种赛马在关节镜手术中应用硫喷妥钠/愈创甘油醚和异丙酚/氯胺酮诱导的回顾性比较。

Q3 Veterinary
Journal of Equine Science Pub Date : 2019-07-01 Epub Date: 2019-07-03 DOI:10.1294/jes.30.25
Hirotaka Tokushige, Masanari Araki, Kanichi Kusano, Daisuke Arima, Hideki Ito, Yosuke Yamazaki, Shuntaro Urayama, Yoshinori Kambayashi, Oki Tateno, Minoru Ohta
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引用次数: 2

摘要

本研究比较了七氟醚和美托咪定麻醉纯种赛马用硫喷妥钠/愈创甘油醚和异丙酚/氯胺酮诱导的临床特征。回顾性检索2015年至2016年期间接受关节镜手术的214匹马的临床记录。先给马注射美托咪定和咪达唑仑,使其达到足够的镇静水平,使其顺利诱导,然后TG组(n=91)或PK组(n=123)分别使用硫喷妥钠(4.0 mg/kg)和愈创甘油醚(100 mg/kg)诱导。七氟醚维持麻醉,匀速输注美托咪定。评估诱导/恢复质量、七氟醚需要量、心血管功能和恢复特征。TG组(5,2 -5)和PK组(5,2 -5)的麻醉诱导评分(中位数,范围)无显著差异。TG组和PK组的尾潮七氟醚浓度(均为2.4±0.2%)差异无统计学意义(平均值±标准差)。多巴酚丁胺输注率(µg/kg/min)在维持平均动脉血压(MAP)高于70 mmHg时,PK组(0.43,0.10-1.40)显著低于TG组(0.67,0.08-1.56)。PK组(5,2 -5)的恢复评分显著高于TG组(4,2 -5)。异丙酚/氯胺酮和硫喷妥钠/愈创尼辛均可顺利诱导麻醉。此外,异丙酚/氯胺酮诱导导致维持期间维持MAP在70 mmHg以上所需的多巴酚丁胺降低,恢复质量更好。在关节镜手术中使用七氟醚和美托咪定麻醉的纯种赛马,异丙酚/氯胺酮诱导优于硫喷妥钠/愈创甘油醚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A retrospective comparison of induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.

This study compares clinical characteristics between induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine. Clinical records of 214 horses that underwent arthroscopic surgery between 2015 and 2016 were retrospectively retrieved. Horses were premedicated with medetomidine and midazolam to sedate at the adequate level for smooth induction, and then induced with either thiopental (4.0 mg/kg) and guaifenesin (100 mg/kg) in Group TG (n=91) or propofol (1.0 mg/kg) and ketamine (1.0 mg/kg) in Group PK (n=123). Anesthesia was maintained using sevoflurane with constant rate infusion of medetomidine. Quality of induction/recovery, sevoflurane requirement, cardiovascular function and recovery characteristics were evaluated. Anesthetic induction scores (median, range) for Group TG (5, 2-5) and Group PK (5, 2-5) were not significantly different. There were no significant differences in end-tidal sevoflurane concentration (mean ± standard deviation) between Group TG and Group PK (both 2.4 ± 0.2%). Dobutamine infusion rate (µg/kg/min) required for keeping mean arterial blood pressure (MAP) above 70 mmHg in Group PK (0.43, 0.10-1.40) was significantly lower than in Group TG (0.67, 0.08-1.56). Recovery score in Group PK (5, 2-5) was significantly higher than in Group TG (4, 2-5). Both propofol/ketamine and thiopental/guaifenesin provided a smooth induction of anesthesia. Moreover, induction with propofol/ketamine resulted in lower dobutamine requirements for keeping MAP above 70 mmHg during maintenance, and better quality of recovery. Induction with propofol/ketamine would be preferable to thiopental/guaifenesin in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.

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来源期刊
Journal of Equine Science
Journal of Equine Science Veterinary-Equine
CiteScore
1.60
自引率
0.00%
发文量
9
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