Shabani Iddi, Caroline A Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R Kidenya, Stephen E Mshana, Mariam M Mirambo
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This study investigated factors associated with liver enzymes abnormalities among human immunodeficiency virus (HIV) infected individuals on ART from the Lake Victoria zone, Tanzania.</p><p><strong>Methods: </strong>A cross-sectional study involving a total of 230 sera from HIV seropositive patients from different regions of the Lake Victoria zone was carried out in July 2017. All samples with required variables/parameters such as age, sex, ART regimen, and residence were serially included in the study. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) detection and liver enzymes assays (alanine transaminase (ALAT) and aspartate transaminase (ASAT)) were assessed following the standard procedures. Data were analyzed by using STATA version 13.</p><p><strong>Results: </strong>The median age of the study participants was 38 (interquartile range [IQR]:30-48) years. The overall prevalence of abnormal liver enzymes was 43.04% (99/230, 95% CI: 36.6-49.3). A total of 26.09% (60/230) had elevated ASAT while 23.9% (55/230) patients had elevated ALAT levels. ASAT levels were significantly high among patients with high HIV viral load (P= 0.002) while ALAT levels were significantly high among those coinfected with hepatitis C virus (P=0.017) and hepatitis B virus (P<0.001).</p><p><strong>Conclusion: </strong>A significant proportion of HIV seropositive individuals on ART have abnormal levels of liver enzymes, which is significantly associated with high HIV viral load and viral hepatitis. This calls for the need to emphasize screening of viral hepatitis and provision of appropriate management among HIV seropositive individuals in this setting.</p>","PeriodicalId":46303,"journal":{"name":"AIDS Research and Treatment","volume":"2019 ","pages":"6375714"},"PeriodicalIF":1.1000,"publicationDate":"2019-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/6375714","citationCount":"4","resultStr":"{\"title\":\"High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretroviral Therapy in the Lake Victoria Zone, Tanzania.\",\"authors\":\"Shabani Iddi, Caroline A Minja, Vitus Silago, Asteria Benjamin, Jastine Mpesha, Shimba Henerico, Benson R Kidenya, Stephen E Mshana, Mariam M Mirambo\",\"doi\":\"10.1155/2019/6375714\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Liver enzymes abnormalities have been found to be common among patients on antiretroviral treatment (ART). Apart from the effects of ART on these changes, other factors that can potentially contribute to the abnormal levels of these enzymes have been found to vary in different geographical locations. This study investigated factors associated with liver enzymes abnormalities among human immunodeficiency virus (HIV) infected individuals on ART from the Lake Victoria zone, Tanzania.</p><p><strong>Methods: </strong>A cross-sectional study involving a total of 230 sera from HIV seropositive patients from different regions of the Lake Victoria zone was carried out in July 2017. All samples with required variables/parameters such as age, sex, ART regimen, and residence were serially included in the study. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) detection and liver enzymes assays (alanine transaminase (ALAT) and aspartate transaminase (ASAT)) were assessed following the standard procedures. Data were analyzed by using STATA version 13.</p><p><strong>Results: </strong>The median age of the study participants was 38 (interquartile range [IQR]:30-48) years. The overall prevalence of abnormal liver enzymes was 43.04% (99/230, 95% CI: 36.6-49.3). A total of 26.09% (60/230) had elevated ASAT while 23.9% (55/230) patients had elevated ALAT levels. ASAT levels were significantly high among patients with high HIV viral load (P= 0.002) while ALAT levels were significantly high among those coinfected with hepatitis C virus (P=0.017) and hepatitis B virus (P<0.001).</p><p><strong>Conclusion: </strong>A significant proportion of HIV seropositive individuals on ART have abnormal levels of liver enzymes, which is significantly associated with high HIV viral load and viral hepatitis. 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引用次数: 4
摘要
背景:肝酶异常在接受抗逆转录病毒治疗(ART)的患者中很常见。除了抗逆转录病毒治疗对这些变化的影响外，还发现其他可能导致这些酶水平异常的因素在不同的地理位置有所不同。本研究调查了来自坦桑尼亚维多利亚湖地区接受抗逆转录病毒治疗的人类免疫缺陷病毒(HIV)感染者肝酶异常的相关因素。方法:于2017年7月对来自维多利亚湖地区不同地区的230例HIV血清阳性患者的血清进行横断面研究。所有具有所需变量/参数(如年龄、性别、ART治疗方案、居住地)的样本依次纳入研究。按照标准程序评估乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)检测和肝酶(丙氨酸转氨酶(ALAT)和天冬氨酸转氨酶(ASAT))。使用STATA version 13对数据进行分析。结果:研究参与者的中位年龄为38岁(四分位数间距[IQR]:30-48岁)。肝酶异常的总体患病率为43.04% (99/230,95% CI: 36.6-49.3)。26.09%(60/230)患者ASAT升高，23.9%(55/230)患者ALAT升高。ASAT水平在HIV病毒载量高的患者中显著升高(P= 0.002)， ALAT水平在同时感染丙型肝炎病毒(P=0.017)和乙型肝炎病毒(P)的患者中显著升高(P=0.017)。结论:ART治疗的HIV血清阳性患者中有相当比例的肝酶水平异常，这与HIV病毒载量高和病毒性肝炎有显著相关性。这就需要强调在这种情况下对艾滋病毒血清阳性个体进行病毒性肝炎筛查并提供适当的管理。
High Human Immunodeficiency Virus (HIV) Viral Load and Coinfection with Viral Hepatitis Are Associated with Liver Enzyme Abnormalities among HIV Seropositive Patients on Antiretroviral Therapy in the Lake Victoria Zone, Tanzania.
Background: Liver enzymes abnormalities have been found to be common among patients on antiretroviral treatment (ART). Apart from the effects of ART on these changes, other factors that can potentially contribute to the abnormal levels of these enzymes have been found to vary in different geographical locations. This study investigated factors associated with liver enzymes abnormalities among human immunodeficiency virus (HIV) infected individuals on ART from the Lake Victoria zone, Tanzania.
Methods: A cross-sectional study involving a total of 230 sera from HIV seropositive patients from different regions of the Lake Victoria zone was carried out in July 2017. All samples with required variables/parameters such as age, sex, ART regimen, and residence were serially included in the study. Hepatitis B virus (HBV) and Hepatitis C virus (HCV) detection and liver enzymes assays (alanine transaminase (ALAT) and aspartate transaminase (ASAT)) were assessed following the standard procedures. Data were analyzed by using STATA version 13.
Results: The median age of the study participants was 38 (interquartile range [IQR]:30-48) years. The overall prevalence of abnormal liver enzymes was 43.04% (99/230, 95% CI: 36.6-49.3). A total of 26.09% (60/230) had elevated ASAT while 23.9% (55/230) patients had elevated ALAT levels. ASAT levels were significantly high among patients with high HIV viral load (P= 0.002) while ALAT levels were significantly high among those coinfected with hepatitis C virus (P=0.017) and hepatitis B virus (P<0.001).
Conclusion: A significant proportion of HIV seropositive individuals on ART have abnormal levels of liver enzymes, which is significantly associated with high HIV viral load and viral hepatitis. This calls for the need to emphasize screening of viral hepatitis and provision of appropriate management among HIV seropositive individuals in this setting.
期刊介绍：
AIDS Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focused on all aspects of HIV and AIDS, from the molecular basis of disease to translational and clinical research. In addition, articles relating to prevention, education, and behavior change will be considered
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