Emilia Urrutia-Maldonado, María Alés-Palmer, Paloma Muñoz De Rueda, Irene Peláez-Pleguezuelos, Esther Ocete-Hita
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引用次数: 0
摘要
背景：杀伤细胞免疫球蛋白样受体（KIRs）及其相关HLA I类配体之间的分子相互作用在调节自然杀伤细胞（NK）的反应中起着核心作用。我们的研究目的是确定KIR基因及其HLA配体在接受肿瘤过程化疗的儿童肝毒性发生的遗传易感性中所起的作用。方法：研究组由22名癌症儿童组成，他们在西班牙格拉纳达Virgen de las Nieves妇产医院儿科肿瘤科接受化疗，并出现药物性肝损伤（DILI）迹象。24名接受类似治疗但没有DILI症状的儿童被选为对照组。结果：具有KIR K2DS2的儿童发生肝毒性的可能性是儿童的4倍（OR=4.08，P=0.034，95%CI:1.1-15）。具有2DS2和C1配体的患者发生肝毒性发作的可能性是患者的10倍（P=0.007）。结论：KIR可能是化疗后易患肝毒性的危险因素。
The relation between activator and inhibitor killer-cell immunoglobulin-like receptors and hepatotoxicity in oncological treatment.
Background: The molecular interactions between killer-cell immunoglobulin-like receptors (KIRs) and their related HLA class I ligands play a central role in regulating the responses of natural killer (NK) cells. Our study aim was to determine the role played by KIR genes and their HLA ligands in the genetic predisposition for the development of hepatotoxicity in children treated with chemotherapy for an oncological process.
Methods: The study group was composed of 22 children with cancer, being treated with chemotherapy at the Unit of Pediatric Oncology of the Maternity Hospital Virgen de las Nieves (Granada, Spain) and presenting signs of drug-induced liver injury (DILI). Twenty-four children receiving similar treatment but presenting no signs of DILI were selected as a control group.
Results: The children with the KIR K2DS2 were four times more likely to have hepatotoxicity (OR=4.08, P=0.034, 95% CI: 1.1-15). The patients with 2DS2 and the C1 ligand were ten times more likely to undergo an episode of hepatotoxicity (P=0.007).
Conclusions: KIRs may be risk factors for susceptibility to hepatotoxicity following chemotherapy.
期刊介绍：
Minerva Pediatrica publishes scientific papers on pediatrics, neonatology, adolescent medicine, child and adolescent psychiatry and pediatric surgery. Manuscripts may be submitted in the form of editorials, original articles, review articles, special articles, letters to the Editor and guidelines. The journal aims to provide its readers with papers of the highest quality and impact through a process of careful peer review and editorial work.
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