颈动脉内膜-中膜厚度:慢性肾病患者心血管疾病的替代标志物

IF 2.3 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Clinical Medicine Insights. Cardiology Pub Date : 2019-06-21 eCollection Date: 2019-01-01 DOI:10.1177/1179546819852941
Olutoyin Morenike Lawal, Michael Olabode Balogun, Anthony Olubunmi Akintomide, Oluwagbemiga Oluwole Ayoola, Tuoyo Omasan Mene-Afejuku, Oluwadare Ogunlade, Oluyomi Oluseun Okunola, Adekunle Oyeyemi Lawal, Adewale Akinsola
{"title":"颈动脉内膜-中膜厚度:慢性肾病患者心血管疾病的替代标志物","authors":"Olutoyin Morenike Lawal,&nbsp;Michael Olabode Balogun,&nbsp;Anthony Olubunmi Akintomide,&nbsp;Oluwagbemiga Oluwole Ayoola,&nbsp;Tuoyo Omasan Mene-Afejuku,&nbsp;Oluwadare Ogunlade,&nbsp;Oluyomi Oluseun Okunola,&nbsp;Adekunle Oyeyemi Lawal,&nbsp;Adewale Akinsola","doi":"10.1177/1179546819852941","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a measure of atherosclerotic vascular disease and considered a comprehensive picture of all alterations caused by multiple cardiovascular risk factors over time on the arterial walls. We therefore sought to determine the CIMT of the common carotid artery in patients with CKD and to evaluate the clinical pattern and prevalence of CVD in CKD patients.</p><p><strong>Methods: </strong>A case-control study involving 100 subjects made of 50 patients with CKD stages 2 to 4 and 50 age and sex matched apparently normal individuals. Carotid intima-media thickness of the common carotid artery was considered thickened if it measured greater than 0.8 mm. All subjects had laboratory investigations, 12-lead electrocardiogram, transthoracic echocardiography, and ankle-brachial index.</p><p><strong>Results: </strong>The mean CIMT was higher in CKD population compared with controls (<i>P</i> < .001). Eighty-four percent of the study population was found to have thickened CIMT compared with 18% of controls (<i>P</i> < .001). Patients with CKD had significantly higher blood pressure and heart rate than controls. Cardiovascular disease was also more prevalent among patients with CKD as compared with controls. Carotid intima-media thickness positively correlated with age, blood pressure, and random blood sugar.</p><p><strong>Conclusions: </strong>As CIMT was well correlated with many cardiovascular risk factors among CKD patients, it may serve as a surrogate marker for CVD and its early assessment may target patients who may need more aggressive therapy to retard the progression of kidney disease and improve outcome.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"13 ","pages":"1179546819852941"},"PeriodicalIF":2.3000,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1179546819852941","citationCount":"11","resultStr":"{\"title\":\"Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.\",\"authors\":\"Olutoyin Morenike Lawal,&nbsp;Michael Olabode Balogun,&nbsp;Anthony Olubunmi Akintomide,&nbsp;Oluwagbemiga Oluwole Ayoola,&nbsp;Tuoyo Omasan Mene-Afejuku,&nbsp;Oluwadare Ogunlade,&nbsp;Oluyomi Oluseun Okunola,&nbsp;Adekunle Oyeyemi Lawal,&nbsp;Adewale Akinsola\",\"doi\":\"10.1177/1179546819852941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a measure of atherosclerotic vascular disease and considered a comprehensive picture of all alterations caused by multiple cardiovascular risk factors over time on the arterial walls. We therefore sought to determine the CIMT of the common carotid artery in patients with CKD and to evaluate the clinical pattern and prevalence of CVD in CKD patients.</p><p><strong>Methods: </strong>A case-control study involving 100 subjects made of 50 patients with CKD stages 2 to 4 and 50 age and sex matched apparently normal individuals. Carotid intima-media thickness of the common carotid artery was considered thickened if it measured greater than 0.8 mm. All subjects had laboratory investigations, 12-lead electrocardiogram, transthoracic echocardiography, and ankle-brachial index.</p><p><strong>Results: </strong>The mean CIMT was higher in CKD population compared with controls (<i>P</i> < .001). Eighty-four percent of the study population was found to have thickened CIMT compared with 18% of controls (<i>P</i> < .001). Patients with CKD had significantly higher blood pressure and heart rate than controls. Cardiovascular disease was also more prevalent among patients with CKD as compared with controls. Carotid intima-media thickness positively correlated with age, blood pressure, and random blood sugar.</p><p><strong>Conclusions: </strong>As CIMT was well correlated with many cardiovascular risk factors among CKD patients, it may serve as a surrogate marker for CVD and its early assessment may target patients who may need more aggressive therapy to retard the progression of kidney disease and improve outcome.</p>\",\"PeriodicalId\":10419,\"journal\":{\"name\":\"Clinical Medicine Insights. Cardiology\",\"volume\":\"13 \",\"pages\":\"1179546819852941\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2019-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/1179546819852941\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Medicine Insights. Cardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/1179546819852941\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Medicine Insights. Cardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1179546819852941","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 11

摘要

背景:心血管疾病(CVD)是慢性肾脏疾病(CKD)患者死亡的主要原因。颈动脉内膜-中膜厚度(CIMT)是衡量动脉粥样硬化性血管疾病的指标,被认为是多种心血管危险因素随时间对动脉壁造成的所有改变的全面描述。因此,我们试图确定CKD患者颈总动脉的CIMT,并评估CKD患者CVD的临床模式和患病率。方法:一项病例对照研究,涉及100名受试者,其中50名CKD 2至4期患者,50名年龄和性别明显正常的个体。如果测量到颈总动脉内膜-中膜厚度大于0.8 mm,则认为颈总动脉增厚。所有受试者均进行了实验室检查、12导联心电图、经胸超声心动图和踝肱指数。结果:CKD人群的平均CIMT高于对照组(P P结论:由于CIMT与CKD患者中许多心血管危险因素密切相关,因此它可能作为CVD的替代标志物,其早期评估可能针对可能需要更积极治疗的患者,以延缓肾脏疾病的进展并改善预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.

Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.

Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.

Carotid Intima-Media Thickness: A Surrogate Marker for Cardiovascular Disease in Chronic Kidney Disease Patients.

Background: Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD). Carotid intima-media thickness (CIMT) is a measure of atherosclerotic vascular disease and considered a comprehensive picture of all alterations caused by multiple cardiovascular risk factors over time on the arterial walls. We therefore sought to determine the CIMT of the common carotid artery in patients with CKD and to evaluate the clinical pattern and prevalence of CVD in CKD patients.

Methods: A case-control study involving 100 subjects made of 50 patients with CKD stages 2 to 4 and 50 age and sex matched apparently normal individuals. Carotid intima-media thickness of the common carotid artery was considered thickened if it measured greater than 0.8 mm. All subjects had laboratory investigations, 12-lead electrocardiogram, transthoracic echocardiography, and ankle-brachial index.

Results: The mean CIMT was higher in CKD population compared with controls (P < .001). Eighty-four percent of the study population was found to have thickened CIMT compared with 18% of controls (P < .001). Patients with CKD had significantly higher blood pressure and heart rate than controls. Cardiovascular disease was also more prevalent among patients with CKD as compared with controls. Carotid intima-media thickness positively correlated with age, blood pressure, and random blood sugar.

Conclusions: As CIMT was well correlated with many cardiovascular risk factors among CKD patients, it may serve as a surrogate marker for CVD and its early assessment may target patients who may need more aggressive therapy to retard the progression of kidney disease and improve outcome.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Clinical Medicine Insights. Cardiology
Clinical Medicine Insights. Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
5.20
自引率
3.30%
发文量
16
审稿时长
8 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信