完整雄性大鼠血液类固醇和甲状腺激素浓度的年龄和认知状态依赖性差异。

IF 4.7 2区 心理学 Q1 BEHAVIORAL SCIENCES
Jovana Maliković, Daniel Daba Feyissa, Predrag Kalaba, Babak Saber Marouf, Harald Höger, Michaela F Hartmann, Stefan A Wudy, Gerhard Schuler, Gert Lubec, Jana Aradska, Volker Korz
{"title":"完整雄性大鼠血液类固醇和甲状腺激素浓度的年龄和认知状态依赖性差异。","authors":"Jovana Maliković,&nbsp;Daniel Daba Feyissa,&nbsp;Predrag Kalaba,&nbsp;Babak Saber Marouf,&nbsp;Harald Höger,&nbsp;Michaela F Hartmann,&nbsp;Stefan A Wudy,&nbsp;Gerhard Schuler,&nbsp;Gert Lubec,&nbsp;Jana Aradska,&nbsp;Volker Korz","doi":"10.1186/s12993-019-0161-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Age-dependent alterations of hormonal states have been considered to be involved in age related decline of cognitive abilities. Most of the studies in animal models are based on hormonal substitution in adrenal- and/or gonadectomized rodents or infusion of steroid hormones in intact rats. Moreover, the manipulations have been done timely, closely related to test procedures, thus reflecting short-term hormonal mechanisms in the regulation of learning and memory. Here we studied whether more general states of steroid and thyroid hormone profiles, independent from acute experiences, may possibly reflect long-term learning capacity. A large cohort of aged (17-18 months) intact male rats were tested in a spatial hole-board learning task and a subset of inferior and superior learners was included into the analysis. Young male adult rats (16 weeks of age) were also tested. Four to 8 weeks after testing blood plasma samples were taken and hormone concentrations of a variety of steroid hormones were measured by gas chromatography-tandem mass spectrometry or radioimmunoassay (17β-estradiol, thyroid hormones).</p><p><strong>Results: </strong>Aged good learners were similar to young rats in the behavioral task. Aged poor learners but not good learners showed higher levels of triiodothyronine (T3) as compared to young rats. Aged good learners had higher levels of thyroid stimulating hormone (TSH) than aged poor learning and young rats. Both aged good and poor learners showed significantly reduced levels of testosterone (T), 4-androstenedione (4A), androstanediol-3α,17β (AD), dihydrotestosterone (DHT), 17-hydroxyprogesterone (17OHP), higher levels of progesterone (Prog) and similar levels of 17β-estradiol (E2) as compared to young rats. The learning, but not the memory indices of all rats were significantly and positively correlated with levels of dihydrotestosterone, androstanediol-3α,17β and thyroxine (T4), when the impacts of age and cognitive division were eliminated by partial correlation analyses.</p><p><strong>Conclusion: </strong>The correlation of hormone concentrations of individuals with individual behavior revealed a possible specific role of these androgen and thyroid hormones in a state of general preparedness to learn.</p>","PeriodicalId":8729,"journal":{"name":"Behavioral and Brain Functions","volume":"15 1","pages":"10"},"PeriodicalIF":4.7000,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12993-019-0161-3","citationCount":"10","resultStr":"{\"title\":\"Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats.\",\"authors\":\"Jovana Maliković,&nbsp;Daniel Daba Feyissa,&nbsp;Predrag Kalaba,&nbsp;Babak Saber Marouf,&nbsp;Harald Höger,&nbsp;Michaela F Hartmann,&nbsp;Stefan A Wudy,&nbsp;Gerhard Schuler,&nbsp;Gert Lubec,&nbsp;Jana Aradska,&nbsp;Volker Korz\",\"doi\":\"10.1186/s12993-019-0161-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Age-dependent alterations of hormonal states have been considered to be involved in age related decline of cognitive abilities. Most of the studies in animal models are based on hormonal substitution in adrenal- and/or gonadectomized rodents or infusion of steroid hormones in intact rats. Moreover, the manipulations have been done timely, closely related to test procedures, thus reflecting short-term hormonal mechanisms in the regulation of learning and memory. Here we studied whether more general states of steroid and thyroid hormone profiles, independent from acute experiences, may possibly reflect long-term learning capacity. A large cohort of aged (17-18 months) intact male rats were tested in a spatial hole-board learning task and a subset of inferior and superior learners was included into the analysis. Young male adult rats (16 weeks of age) were also tested. Four to 8 weeks after testing blood plasma samples were taken and hormone concentrations of a variety of steroid hormones were measured by gas chromatography-tandem mass spectrometry or radioimmunoassay (17β-estradiol, thyroid hormones).</p><p><strong>Results: </strong>Aged good learners were similar to young rats in the behavioral task. Aged poor learners but not good learners showed higher levels of triiodothyronine (T3) as compared to young rats. Aged good learners had higher levels of thyroid stimulating hormone (TSH) than aged poor learning and young rats. Both aged good and poor learners showed significantly reduced levels of testosterone (T), 4-androstenedione (4A), androstanediol-3α,17β (AD), dihydrotestosterone (DHT), 17-hydroxyprogesterone (17OHP), higher levels of progesterone (Prog) and similar levels of 17β-estradiol (E2) as compared to young rats. The learning, but not the memory indices of all rats were significantly and positively correlated with levels of dihydrotestosterone, androstanediol-3α,17β and thyroxine (T4), when the impacts of age and cognitive division were eliminated by partial correlation analyses.</p><p><strong>Conclusion: </strong>The correlation of hormone concentrations of individuals with individual behavior revealed a possible specific role of these androgen and thyroid hormones in a state of general preparedness to learn.</p>\",\"PeriodicalId\":8729,\"journal\":{\"name\":\"Behavioral and Brain Functions\",\"volume\":\"15 1\",\"pages\":\"10\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2019-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s12993-019-0161-3\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Behavioral and Brain Functions\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1186/s12993-019-0161-3\",\"RegionNum\":2,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BEHAVIORAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Behavioral and Brain Functions","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1186/s12993-019-0161-3","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 10

摘要

背景:激素状态的年龄依赖性改变被认为与年龄相关的认知能力下降有关。大多数动物模型的研究都是基于肾上腺和/或性腺去角质啮齿动物的激素替代或完整大鼠的类固醇激素输注。此外,这些操作都是及时的,与测试程序密切相关,从而反映了学习和记忆调节中的短期激素机制。在这里,我们研究了类固醇和甲状腺激素谱的一般状态是否独立于急性经验,可能反映长期学习能力。我们对17-18个月的成年雄性大鼠进行了空间孔板学习任务测试,并将学习能力较差和较强的大鼠分别纳入分析。年轻雄性成年大鼠(16周龄)也进行了测试。检测后4 ~ 8周,取血浆标本,采用气相色谱-串联质谱法或放射免疫分析法(17β-雌二醇、甲状腺激素)测定多种类固醇激素的激素浓度。结果:老年良好学习者在行为任务上与青年大鼠相似。与年轻大鼠相比,学习能力差但学习能力不佳的老年大鼠的三碘甲状腺原氨酸(T3)水平更高。老年学习能力强的大鼠的促甲状腺激素(TSH)水平高于老年学习能力差的大鼠和年轻大鼠。与年轻大鼠相比,老年学习成绩好的和学习成绩差的大鼠睾酮(T)、4-雄烯二酮(4A)、雄烯二醇-3α、17β (AD)、二氢睾酮(DHT)、17-羟基孕酮(17OHP)水平均显著降低,孕酮(Prog)水平较高,17β -雌二醇(E2)水平相似。在部分相关分析中消除年龄和认知划分的影响后,所有大鼠的学习指标与双氢睾酮、雄甾二醇-3α、17β和甲状腺素(T4)水平呈显著正相关,而记忆指标与之呈显著正相关。结论:个体激素浓度与个体行为的相关性揭示了这些雄激素和甲状腺激素在一般学习准备状态中的特定作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats.

Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats.

Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats.

Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats.

Background: Age-dependent alterations of hormonal states have been considered to be involved in age related decline of cognitive abilities. Most of the studies in animal models are based on hormonal substitution in adrenal- and/or gonadectomized rodents or infusion of steroid hormones in intact rats. Moreover, the manipulations have been done timely, closely related to test procedures, thus reflecting short-term hormonal mechanisms in the regulation of learning and memory. Here we studied whether more general states of steroid and thyroid hormone profiles, independent from acute experiences, may possibly reflect long-term learning capacity. A large cohort of aged (17-18 months) intact male rats were tested in a spatial hole-board learning task and a subset of inferior and superior learners was included into the analysis. Young male adult rats (16 weeks of age) were also tested. Four to 8 weeks after testing blood plasma samples were taken and hormone concentrations of a variety of steroid hormones were measured by gas chromatography-tandem mass spectrometry or radioimmunoassay (17β-estradiol, thyroid hormones).

Results: Aged good learners were similar to young rats in the behavioral task. Aged poor learners but not good learners showed higher levels of triiodothyronine (T3) as compared to young rats. Aged good learners had higher levels of thyroid stimulating hormone (TSH) than aged poor learning and young rats. Both aged good and poor learners showed significantly reduced levels of testosterone (T), 4-androstenedione (4A), androstanediol-3α,17β (AD), dihydrotestosterone (DHT), 17-hydroxyprogesterone (17OHP), higher levels of progesterone (Prog) and similar levels of 17β-estradiol (E2) as compared to young rats. The learning, but not the memory indices of all rats were significantly and positively correlated with levels of dihydrotestosterone, androstanediol-3α,17β and thyroxine (T4), when the impacts of age and cognitive division were eliminated by partial correlation analyses.

Conclusion: The correlation of hormone concentrations of individuals with individual behavior revealed a possible specific role of these androgen and thyroid hormones in a state of general preparedness to learn.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Behavioral and Brain Functions
Behavioral and Brain Functions 医学-行为科学
CiteScore
5.90
自引率
0.00%
发文量
11
审稿时长
6-12 weeks
期刊介绍: A well-established journal in the field of behavioral and cognitive neuroscience, Behavioral and Brain Functions welcomes manuscripts which provide insight into the neurobiological mechanisms underlying behavior and brain function, or dysfunction. The journal gives priority to manuscripts that combine both neurobiology and behavior in a non-clinical manner.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信