儿童和青少年继发性高血压:新见解。

IF 1.5 Q3 PERIPHERAL VASCULAR DISEASE
Katerina Chrysaidou, Athanasia Chainoglou, Vasiliki Karava, John Dotis, Nikoleta Printza, Stella Stabouli
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引用次数: 13

摘要

高血压是心血管疾病发病率和死亡率的重要危险因素,不仅在成年人中,而且在年轻人中也是如此,因为它与长期的负面健康影响有关。儿童高血压的主要类型是继发性高血压,慢性肾脏疾病是最常见的原因,但现在,由于儿童肥胖发病率的上升,原发性高血压的发病率也在上升。虽然办公室血压指导患者管理多年,动态血压监测提供了有用的信息,促进了儿童和青少年高血压的诊断和管理,通过监测治疗和评估继发原因或高血压的特定表型。在继发性高血压领域,有大量研究报道了24小时血压特征的不同决定因素与潜在原因之间的密切联系。此外,在继发性高血压儿童中,动态血压监测参数提供了独特的优势,以识别儿童低和高危儿童靶器官损伤。关于高血压发病机制的新见解,包括围产期因素或新的心血管生物标志物(如成纤维细胞生长因子23)的作用,需要在不久的将来进一步评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Secondary Hypertension in Children and Adolescents: Novel Insights.

Hypertension is a significant risk factor for cardiovascular morbidity and mortality, not only in adults, but in youths also, as it is associated with long-term negative health effects. The predominant type of hypertension in children is the secondary hypertension, with the chronic kidney disease being the most common cause, however, nowadays, there is a rising incidence of primary hypertension due to the rising incidence of obesity in children. Although office blood pressure has guided patient management for many years, ambulatory blood pressure monitoring provides useful information, facilitates the diagnosis and management of hypertension in children and adolescents, by monitoring treatment and evaluation for secondary causes or specific phenotypes of hypertension. In the field of secondary hypertension, there are numerous studies, which have reported a strong association between different determinants of 24-hour blood pressure profile and the underlying cause. In addition, in children with secondary hypertension, ambulatory blood pressure monitoring parameters offer the unique advantage to identify pediatric low- and high-risk children for target organ damage. Novel insights in the pathogenesis of hypertension, including the role of perinatal factors or new cardiovascular biomarkers, such as fibroblast growth factor 23, need to be further evaluated in the near future.

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来源期刊
Current Hypertension Reviews
Current Hypertension Reviews PERIPHERAL VASCULAR DISEASE-
CiteScore
4.80
自引率
0.00%
发文量
26
期刊介绍: Current Hypertension Reviews publishes frontier reviews/ mini-reviews, original research articles and guest edited thematic issues on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal’s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.
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