耐力体力活动后HTR2C基因变异与唾液皮质醇水平:一项初步研究。

IF 2 4区医学 Q3 GENETICS & HEREDITY

Lifestyle Genomics Pub Date : 2018-01-01 Epub Date: 2019-06-05 DOI:10.1159/000499842

Laura Bordoni, Donatella Fedeli, Marco Piangerelli, Rosita Gabbianelli

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引用次数: 1

摘要

5-羟色胺2C受体(HTR2C) rs6318多态性与应激敏感性增加有关。本研究探讨了rs6318基因型是否改变了皮质醇对耐力体力活动的反应。方法:在一群激动性自行车运动员中对HTR2C SNP进行基因分型，并在耐力比赛前后测量唾液皮质醇水平。结果与结论:比赛后唾液皮质醇水平升高，由20.72±12.36 ng/mL升高至33.80±21.53 ng/mL;P = 3.189 × 10-5)。rs6318 C携带者的皮质醇基线水平高于G携带者(26.60±9.35 ng/mL vs. 19.50±12.63 ng/mL);P = 0.04)。基线皮质醇水平能够预测运动后的皮质醇反应(β = -0.846;P = 1.2 × 10-5)。虽然回归分析没有确定HTR2C基因型与皮质醇水平变化之间的关联，但根据皮质醇变化中位数对人群进行分类的二次分析表明，它们可能存在弱相关性，因此值得进一步研究。

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HTR2C Gene Variant and Salivary Cortisol Levels after Endurance Physical Activity: A Pilot Study.

Introduction: The 5-hydroxytryptamine 2C receptor (HTR2C) rs6318 polymorphism has been associated with increased sensitivity to stress. This study investigated whether the rs6318 genotype modified the cortisol response to endurance physical activity.

Methods: The HTR2C SNP was genotyped in a population of agonistic cyclists, and salivary cortisol levels were measured before and after an endurance competition.

Results and conclusion: Salivary cortisol levels increased after the competition (from 20.72 ± 12.36 ng/mL to 33.80 ± 21.53 ng/mL; p = 3.189 × 10-5). rs6318 C carriers displayed higher baseline cortisol levels compared to G carriers (26.60 ± 9.35 ng/mL vs. 19.50 ± 12.63 ng/mL; p = 0.04). Baseline cortisol levels were able to predict the cortisol response to exercise (β = -0.846; p = 1.2 × 10-5). Although regression analysis did not identify an association between HTR2C genotype and change in cortisol levels, a secondary analysis in which the population was classified by median cortisol changes suggested that they might be weakly associated, thus warranting further investigation.

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来源期刊

Lifestyle Genomics Agricultural and Biological Sciences-Food Science

CiteScore

4.00

自引率

7.70%

发文量

审稿时长

28 weeks

期刊介绍： Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.