耐力体力活动后HTR2C基因变异与唾液皮质醇水平:一项初步研究。

IF 2 4区医学 Q3 GENETICS & HEREDITY

Lifestyle Genomics Pub Date : 2018-01-01 Epub Date: 2019-06-05 DOI:10.1159/000499842

Laura Bordoni, Donatella Fedeli, Marco Piangerelli, Rosita Gabbianelli

{"title":"耐力体力活动后HTR2C基因变异与唾液皮质醇水平:一项初步研究。","authors":"Laura Bordoni, Donatella Fedeli, Marco Piangerelli, Rosita Gabbianelli","doi":"10.1159/000499842","DOIUrl":null,"url":null,"abstract":"Introduction: The 5-hydroxytryptamine 2C receptor (HTR2C) rs6318 polymorphism has been associated with increased sensitivity to stress. This study investigated whether the rs6318 genotype modified the cortisol response to endurance physical activity.Methods: The HTR2C SNP was genotyped in a population of agonistic cyclists, and salivary cortisol levels were measured before and after an endurance competition.Results and conclusion: Salivary cortisol levels increased after the competition (from 20.72 ± 12.36 ng/mL to 33.80 ± 21.53 ng/mL; p = 3.189 × 10-5). rs6318 C carriers displayed higher baseline cortisol levels compared to G carriers (26.60 ± 9.35 ng/mL vs. 19.50 ± 12.63 ng/mL; p = 0.04). Baseline cortisol levels were able to predict the cortisol response to exercise (β = -0.846; p = 1.2 × 10-5). Although regression analysis did not identify an association between HTR2C genotype and change in cortisol levels, a secondary analysis in which the population was classified by median cortisol changes suggested that they might be weakly associated, thus warranting further investigation.","PeriodicalId":18030,"journal":{"name":"Lifestyle Genomics","volume":"11 3-6","pages":"163-167"},"PeriodicalIF":2.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000499842","citationCount":"1","resultStr":"{\"title\":\"HTR2C Gene Variant and Salivary Cortisol Levels after Endurance Physical Activity: A Pilot Study.\",\"authors\":\"Laura Bordoni, Donatella Fedeli, Marco Piangerelli, Rosita Gabbianelli\",\"doi\":\"10.1159/000499842\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: The 5-hydroxytryptamine 2C receptor (HTR2C) rs6318 polymorphism has been associated with increased sensitivity to stress. This study investigated whether the rs6318 genotype modified the cortisol response to endurance physical activity.Methods: The HTR2C SNP was genotyped in a population of agonistic cyclists, and salivary cortisol levels were measured before and after an endurance competition.Results and conclusion: Salivary cortisol levels increased after the competition (from 20.72 ± 12.36 ng/mL to 33.80 ± 21.53 ng/mL; p = 3.189 × 10-5). rs6318 C carriers displayed higher baseline cortisol levels compared to G carriers (26.60 ± 9.35 ng/mL vs. 19.50 ± 12.63 ng/mL; p = 0.04). Baseline cortisol levels were able to predict the cortisol response to exercise (β = -0.846; p = 1.2 × 10-5). Although regression analysis did not identify an association between HTR2C genotype and change in cortisol levels, a secondary analysis in which the population was classified by median cortisol changes suggested that they might be weakly associated, thus warranting further investigation.\",\"PeriodicalId\":18030,\"journal\":{\"name\":\"Lifestyle Genomics\",\"volume\":\"11 3-6\",\"pages\":\"163-167\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000499842\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lifestyle Genomics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000499842\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/6/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lifestyle Genomics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000499842","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/6/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 1

摘要

5-羟色胺2C受体(HTR2C) rs6318多态性与应激敏感性增加有关。本研究探讨了rs6318基因型是否改变了皮质醇对耐力体力活动的反应。方法:在一群激动性自行车运动员中对HTR2C SNP进行基因分型，并在耐力比赛前后测量唾液皮质醇水平。结果与结论:比赛后唾液皮质醇水平升高，由20.72±12.36 ng/mL升高至33.80±21.53 ng/mL;P = 3.189 × 10-5)。rs6318 C携带者的皮质醇基线水平高于G携带者(26.60±9.35 ng/mL vs. 19.50±12.63 ng/mL);P = 0.04)。基线皮质醇水平能够预测运动后的皮质醇反应(β = -0.846;P = 1.2 × 10-5)。虽然回归分析没有确定HTR2C基因型与皮质醇水平变化之间的关联，但根据皮质醇变化中位数对人群进行分类的二次分析表明，它们可能存在弱相关性，因此值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

HTR2C Gene Variant and Salivary Cortisol Levels after Endurance Physical Activity: A Pilot Study.

Introduction: The 5-hydroxytryptamine 2C receptor (HTR2C) rs6318 polymorphism has been associated with increased sensitivity to stress. This study investigated whether the rs6318 genotype modified the cortisol response to endurance physical activity.

Methods: The HTR2C SNP was genotyped in a population of agonistic cyclists, and salivary cortisol levels were measured before and after an endurance competition.

Results and conclusion: Salivary cortisol levels increased after the competition (from 20.72 ± 12.36 ng/mL to 33.80 ± 21.53 ng/mL; p = 3.189 × 10-5). rs6318 C carriers displayed higher baseline cortisol levels compared to G carriers (26.60 ± 9.35 ng/mL vs. 19.50 ± 12.63 ng/mL; p = 0.04). Baseline cortisol levels were able to predict the cortisol response to exercise (β = -0.846; p = 1.2 × 10-5). Although regression analysis did not identify an association between HTR2C genotype and change in cortisol levels, a secondary analysis in which the population was classified by median cortisol changes suggested that they might be weakly associated, thus warranting further investigation.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Lifestyle Genomics Agricultural and Biological Sciences-Food Science

CiteScore

4.00

自引率

7.70%

发文量

审稿时长

28 weeks

期刊介绍： Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.