Moritz P Herle, Carol Kan, Kaushalya Jayaweera, Anushka Adikari, Sisira Siribaddana, Helena M S Zavos, Milana Smolkina, Athula Sumathipala, Clare Llewellyn, Khalida Ismail, Matthew Hotopf, Janet Treasure, Frühling Rijsdijk
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引用次数: 5
摘要
本研究利用遗传模型拟合分析，调查了斯里兰卡人群中情绪暴饮暴食(EOE)和抑郁症状的遗传和环境因素及其共变。在科伦坡双胞胎和单胞胎研究-第2阶段中，总共有3957名双胞胎和单胞胎对他们的EOE行为和抑郁症状进行了评分，这两者之间存在显著相关性(男性:r = 0.11, 95%可信区间(CI) 0.06-0.16，女性:r = 0.12, 95%可信区间(CI) 0.07-0.16)。非共享环境因素解释了男性的大部分差异(eoee2 = 87%， 95% CI 78-95%;抑郁症状e2 = 72%， 95% CI 61-83%)和女性(EOE e2 = 76%， 95% CI 68-83%;抑郁症状e2 = 64%， 95% CI 55-74%)。遗传因素对女性EOE的影响(h2 = 21%， 95% CI 4-32%)大于男性(h2 = 9%， 95% CI 0-20%)。共同环境因素对男性抑郁症状的影响(c2 = 25%， 95% CI 10-36%)大于女性(c2 = 9%， 95% CI 0-35%)。非共享的环境因素解释了女性抑郁症状和EOE之间的重叠，而不是男性。结果与高收入人群不同，这突出了在全球人群中进行行为遗传学研究的必要性。
The association between emotional eating and depressive symptoms: a population-based twin study in Sri Lanka.
This study investigated the genetic and environmental contributions to emotional overeating (EOE) and depressive symptoms, and their covariation, in a Sri-Lankan population, using genetic model-fitting analysis. In total, 3957 twins and singletons in the Colombo Twin and Singleton Study-Phase 2 rated their EOE behaviour and depressive symptoms, which were significantly associated (men: r = 0.11, 95% confidence interval (CI) 0.06-0.16, women: r = 0.12, 95% CI 0.07-0.16). Non-shared environmental factors explained the majority of variance in men (EOE e2 = 87%, 95% CI 78-95%; depressive symptoms e2 = 72%, 95% CI 61-83%) and women (EOE e2 = 76%, 95% CI 68-83%; depressive symptoms e2 = 64%, 95% CI 55-74%). Genetic factors were more important for EOE in women (h2 = 21%, 95% CI 4-32%) than men (h2 = 9%, 95% CI 0-20%). Shared-environmental factors were more important for depressive symptoms in men (c2 = 25%, 95% CI 10-36%) than women (c2 = 9%, 95% CI 0-35%). Non-shared environmental factors explained the overlap between depressive symptoms and EOE in women but not in men. Results differed from high-income populations, highlighting the need for behavioural genetic research in global populations.
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