氯诺昔康联合小剂量氯胺酮与哌啶控制急性肾绞痛疼痛的比较。

Q2 Medicine
Pain Research and Treatment Pub Date : 2019-03-13 eCollection Date: 2019-01-01 DOI:10.1155/2019/3976027
Ayman A Metry, Neven G Fahmy, George M Nakhla, Rami M Wahba, Milad Z Ragaei, Fady A Abdelmalek
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引用次数: 5

摘要

目的:本研究旨在比较单剂量氯诺昔康8mg (NSAID)和0.15 mg。kg-1氯胺酮联合单剂量哌啶50mg,均静脉(IV)给药,关于镇痛的速度和程度、缺点和对实用情况的影响。患者和方法:120例急诊急性肾绞痛患者纳入前瞻性、随机、双盲临床研究。根据电脑生成的表格,他们被漫无目的地分为两组。L组给予氯诺昔康8mg IV + 0.15 mg;kg-1氯胺酮,P组给予哌替啶50 mg IV。分别于基线及给药后0、15、30、45分钟和1小时观察参数。通过观察患者的疼痛程度、疼痛缓解时间、疼痛复发率、是否需要抢救止痛、不良事件和功能状态来确定药物的有效性。结果:30 min后,L组的视觉模拟评分明显低于P组。30 min后,P组的抢救性镇痛需求明显高于L组,P组镇静评分较L组无显著升高。接受氯诺昔康-氯胺酮治疗的患者疼痛评分降低幅度更大,副作用更少,功能状态更好,而且与使用哌啶治疗急性肾绞痛的患者相比,需要进一步镇痛的可能性更小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Lornoxicam with Low-Dose Ketamine versus Pethidine to Control Pain of Acute Renal Colic.

Lornoxicam with Low-Dose Ketamine versus Pethidine to Control Pain of Acute Renal Colic.

Objectives: This study was established to compare single-dose lornoxicam 8 mg (NSAID) in addition to 0.15 mg.kg-1 ketamine with single-dose pethidine 50 mg, both administered intravenously (IV), on the quickness and extent of analgesia, disadvantage, and consequence on utilitarian situation.

Patients and methods: One hundred and twenty patients with acute renal colic pain received in emergency room were included in this prospective, randomized, and double blind clinical study. They were aimlessly designated into one of two groups using a computer-generated table. Group L received lornoxicam 8 mg IV plus 0.15 mg.kg-1 ketamine and Group P received pethidine 50 mg IV. Parameters were noticed at baseline and after 0, 15, 30, and 45 minutes and 1 hour after drug administration. The efficiency of the drug was determined by observing: patient rated pain, time to pain relief, rate of pain recurrence, the need for rescue analgesia, adverse events, and functional status.

Results: The visual analogue scale was significantly lower in Group L after 30 minutes in comparison to Group P. In addition, there was statistically significant increase in Group P regarding their need for rescue analgesia after 30 min in comparison to Group L. Group P showed nonsignificantly increased sedation score compared to Group L.

Conclusion: Patients receiving lornoxicam-ketamine attained greater reduction in pain scores and less side effects with better functional state and also are less likely to require further analgesia than those administered pethidine to control acute renal colic pain.

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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
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0.00%
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