马拉维恶性黑色素瘤的流行病学和组织病理学特征。

Q2 Medicine
BMC Clinical Pathology Pub Date : 2019-04-02 eCollection Date: 2019-01-01 DOI:10.1186/s12907-019-0087-6
Maurice Mulenga, Nathan D Montgomery, Maganizo Chagomerana, Tenganawo Mzumala, Tamiwe Tomoka, Coxcilly Kampani, Yuri Fedoriw, Satish Gopal, Lisbet Sviland
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引用次数: 9

摘要

背景:关于恶性黑色素瘤的研究主要集中在高加索人群,因为浅色皮肤的人发病率更高。虽然有大量文献描述了非裔美国人的黑色素瘤,但对非洲黑人的黑色素瘤知之甚少。先前的报告表明,在非洲黑人中极为罕见,他们被认为主要患有肢端黄斑亚型。然而,在世界的这一部分,对黑色素瘤的准确理解受到先前出版物非常有限的性质的阻碍。本研究的目的是确定在马拉维三级转诊医院非洲人黑色素瘤的流行病学概况、解剖分布和组织病理学特征。方法:这是一项回顾性研究,研究了2012年1月至2017年12月在马拉维癌症转诊中心诊断的黑色素瘤病例。检索研究期间所有确诊的恶性黑色素瘤病例。提取的数据包括年龄、性别、解剖部位以及是否为原发或转移部位。brreslow厚度(以毫米为单位)、Clark侵袭程度、溃疡的存在和黑色素瘤亚型也进行了评估。结果:132例纳入研究,81例(61%)为女性,26例(20%)来自转移部位。平均年龄为57岁(sd = 15),以60-69岁年龄组居多。男性出现的年龄比女性大。95%的皮肤黑色素瘤位于肢端部位,最常见的是足部(87%),最常见的组织病理学亚型是肢端黄斑。84%的患者表现为布雷斯洛厚度超过4毫米(中位数为9毫米)。结论:我们的研究表明恶性黑色素瘤发生在马拉维的黑人中,可能是一种未被重视的恶性肿瘤。虽然没有长期的临床随访,但大多数患者在疾病晚期出现,预后较差。这些结果表明,提高对非洲黑人黑色素瘤的认识和早期干预可能对预后和生存率有重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epidemiological and histopathological profile of malignant melanoma in Malawi.

Epidemiological and histopathological profile of malignant melanoma in Malawi.

Background: Studies on malignant melanoma have largely focused on Caucasian populations due to higher incidence in lighter-skinned individuals. While there is a well developed body of literature describing melanoma in African-Americans, much less is known about melanoma in black Africans. Prior reports have suggested that it is reportedly extremely rare in black Africans who are considered to mostly have the acral lentiginous subtype. However, an accurate understanding of melanoma in this part of the world is hindered by the very limited nature of prior publications. The aim of this study was to determine the epidemiological profile, anatomical distribution and histopathological features of melanoma presenting in Africans at a tertiary referral hospital in Malawi.

Methods: This is a retrospective study that characterized melanoma cases diagnosed from January 2012 to December 2017, at a cancer referral centre in Malawi. All confirmed, malignant melanoma cases during the study period were retrieved. Data abstracted included age, sex, anatomic site and whether it was a primary or metastatic site. Breslow thickness in millimetres, Clark level of invasion, presence of ulceration and melanoma subtype were also evaluated.

Results: One hundred thirty-two cases were included in the study, 81 (61%) were female and 26 (20%) were from a metastatic site. The mean age was 57 years (sd = 15) with the majority in the age group 60-69 years. Males presented at an older age than females. Ninety five percent of cutaneous melanomas were located on acral sites, most commonly the foot (87%) and the most common histopathological subtype was acral lentiginous. Eighty four percent presented with a Breslow thickness over 4 mm (median 9 mm).

Conclusion: Our study shows that malignant melanoma occurs in black people in Malawi and may be an under-appreciated malignancy. While long term clinical follow-up was not available, most patients presented at late stages of the disease, supporting a poor prognosis. These results suggest that increased awareness of melanoma in black Africans and earlier intervention may have meaningful impacts on outcomes and survival.

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来源期刊
BMC Clinical Pathology
BMC Clinical Pathology Medicine-Pathology and Forensic Medicine
CiteScore
3.30
自引率
0.00%
发文量
0
期刊介绍: BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.
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