Ibrahim M Shokry, Kayla DeSuza, John J Callanan, Giselle Shim, Zhiyuan Ma, Rui Tao
{"title":"患有甲状腺机能亢进的个体在服用MDMA(摇头丸)后更容易出现严重的血清素综合征。","authors":"Ibrahim M Shokry, Kayla DeSuza, John J Callanan, Giselle Shim, Zhiyuan Ma, Rui Tao","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In a recreational use of 3,4-methylenedioxymethamphetamine (MDMA, \"Ecstasy\"), some but not all users are stricken with a serious serotonin (<i>5</i>-hydroxytryptamine; <i>5</i>-HT) syndrome. This raises a question as to whether there exist subpopulations that are more susceptible to MDMA intoxication. The hypothesis was tested with hyperthyroid versus euthyroid rats by measuring changes in body-core temperature (<i>T</i> <sub>cor</sub>) and <i>5</i>-HT in the hypothalamus. In the euthyroid rats, injection of MDMA at a recreationally relevant dose had no serious effect on <i>T</i> <sub>cor</sub>. In contrast, the same dose was sufficient to evoke life-threatening hyperthermia in hyperthyroid rats. Neurochemical studies revealed that there was greater <i>5</i>-HT efflux in the hyperthyroid than the euthyroid rats. These effects were blocked by pretreatment with M100907, a <i>5</i>-HT<sub>2A</sub> receptor antagonist. In summary, our data support the hypothesis that individuals with hyperthyroidism are more susceptible to having a serious serotonin syndrome following MDMA administration.</p>","PeriodicalId":92167,"journal":{"name":"Annals of forensic research and analysis","volume":"5 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548465/pdf/nihms-1026785.pdf","citationCount":"0","resultStr":"{\"title\":\"Individuals with Hyperthyroidism are More Susceptible to having a Serious Serotonin Syndrome Following MDMA (Ecstasy) Administration in Rats.\",\"authors\":\"Ibrahim M Shokry, Kayla DeSuza, John J Callanan, Giselle Shim, Zhiyuan Ma, Rui Tao\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In a recreational use of 3,4-methylenedioxymethamphetamine (MDMA, \\\"Ecstasy\\\"), some but not all users are stricken with a serious serotonin (<i>5</i>-hydroxytryptamine; <i>5</i>-HT) syndrome. This raises a question as to whether there exist subpopulations that are more susceptible to MDMA intoxication. The hypothesis was tested with hyperthyroid versus euthyroid rats by measuring changes in body-core temperature (<i>T</i> <sub>cor</sub>) and <i>5</i>-HT in the hypothalamus. In the euthyroid rats, injection of MDMA at a recreationally relevant dose had no serious effect on <i>T</i> <sub>cor</sub>. In contrast, the same dose was sufficient to evoke life-threatening hyperthermia in hyperthyroid rats. Neurochemical studies revealed that there was greater <i>5</i>-HT efflux in the hyperthyroid than the euthyroid rats. These effects were blocked by pretreatment with M100907, a <i>5</i>-HT<sub>2A</sub> receptor antagonist. In summary, our data support the hypothesis that individuals with hyperthyroidism are more susceptible to having a serious serotonin syndrome following MDMA administration.</p>\",\"PeriodicalId\":92167,\"journal\":{\"name\":\"Annals of forensic research and analysis\",\"volume\":\"5 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548465/pdf/nihms-1026785.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of forensic research and analysis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/11/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of forensic research and analysis","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/11/12 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Individuals with Hyperthyroidism are More Susceptible to having a Serious Serotonin Syndrome Following MDMA (Ecstasy) Administration in Rats.
In a recreational use of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"), some but not all users are stricken with a serious serotonin (5-hydroxytryptamine; 5-HT) syndrome. This raises a question as to whether there exist subpopulations that are more susceptible to MDMA intoxication. The hypothesis was tested with hyperthyroid versus euthyroid rats by measuring changes in body-core temperature (Tcor) and 5-HT in the hypothalamus. In the euthyroid rats, injection of MDMA at a recreationally relevant dose had no serious effect on Tcor. In contrast, the same dose was sufficient to evoke life-threatening hyperthermia in hyperthyroid rats. Neurochemical studies revealed that there was greater 5-HT efflux in the hyperthyroid than the euthyroid rats. These effects were blocked by pretreatment with M100907, a 5-HT2A receptor antagonist. In summary, our data support the hypothesis that individuals with hyperthyroidism are more susceptible to having a serious serotonin syndrome following MDMA administration.
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