雌激素、压力和抑郁:认知和生物学的相互作用。

IF 17.8 1区 心理学 Q1 PSYCHOLOGY
Kimberly M Albert, Paul A Newhouse
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引用次数: 90

摘要

本文综述了雌激素变化和社会心理压力在促进女性易患重度抑郁症(MDD)中的相互作用。雌激素调节与应激反应、认知和情绪失调变化相关的大脑网络和过程,这些变化是重度抑郁症的核心特征。雌激素对认知和情绪功能的协同作用,特别是在心理社会压力期间,可能是卵巢激素波动与妇女抑郁之间关联的基础。我们提出了雌激素对多个脑系统的影响模型,这些脑系统与MDD中涉及的压力相关的情绪和认知过程相连接,并讨论了生殖事件和雌激素变化可能导致女性MDD风险的机制,以及其他并发风险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

Estrogen, Stress, and Depression: Cognitive and Biological Interactions.

This article reviews the interactions of estrogen changes and psychosocial stress in contributing to vulnerability to major depressive disorder (MDD) in women. Estrogen modulates brain networks and processes related to changes in stress response, cognition, and emotional dysregulation that are core characteristics of MDD. Synergistic effects of estrogen on cognitive and emotional function, particularly during psychosocial stress, may underlie the association of ovarian hormone fluctuation and depression in women. We propose a model of estrogen effects on multiple brain systems that interface with stress-related emotional and cognitive processes implicated in MDD and discuss possible mechanisms through which reproductive events and changes in estrogen may contribute to MDD risk in women with other concurrent risk factors.

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来源期刊
CiteScore
31.50
自引率
0.50%
发文量
24
期刊介绍: The Annual Review of Clinical Psychology is a publication that has been available since 2005. It offers comprehensive reviews on significant developments in the field of clinical psychology and psychiatry. The journal covers various aspects including research, theory, and the application of psychological principles to address recognized disorders such as schizophrenia, mood, anxiety, childhood, substance use, cognitive, and personality disorders. Additionally, the articles also touch upon broader issues that cut across the field, such as diagnosis, treatment, social policy, and cross-cultural and legal issues. Recently, the current volume of this journal has transitioned from a gated access model to an open access format through the Annual Reviews' Subscribe to Open program. All articles published in this volume are now available under a Creative Commons Attribution License (CC BY), allowing for widespread distribution and use. The journal is also abstracted and indexed in various databases including Scopus, Science Citation Index Expanded, MEDLINE, EMBASE, CINAHL, PsycINFO, and Academic Search, among others.
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