沃尔巴克氏体作为抗寄生虫药物靶点和生态友好型生物防治剂的前景研究。

Q3 Medicine
Tooran Nayeri Chegeni, Mahdi Fakhar
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引用次数: 2

摘要

背景:沃尔巴克氏体是虫媒寄生虫中最常见的内共生细菌,是世界上最常见的生殖寄生虫。沃尔巴克氏体在世界各地的许多节肢动物和寄生虫物种中被发现,包括昆虫、陆生等足动物、蜘蛛、螨虫和丝状线虫。沃尔巴克氏体和它的宿主之间有一种复杂的关系,在某些情况下,它们创造了一种相互关系,而不是寄生关系。有些物种在没有沃尔巴克氏体感染的情况下无法繁殖。因此,利用现有的沃尔巴克氏菌菌株为控制蚊子种群和其他病虫害提供了一种潜在的策略。方法:检索10个数据库,回顾1996年至2017年(22年)关于沃尔巴克氏体作为一种有前景的药物靶点和新兴寄生虫病生物防治剂作用的已发表论文。此外,本研究还审查了几项专利(WO008652)、(US7723062)和(US 0345249 A1)。结果:从母体遗传的内共生沃尔巴克氏菌可通过蚊虫传播,干扰病原体传播。它们可以改变宿主的繁殖。沃尔巴克氏体通过卵子的细胞质传播,并进化出不同的机制来操纵宿主的繁殖,包括诱导生殖不相容、孤雌生殖和雌性化。沃尔巴克氏体对生殖和宿主适应性的广泛影响使得沃尔巴克氏体作为一种潜在的生物防治剂日益受到关注。结论:沃尔巴克氏体为设计一种昂贵、有效、环保的药物靶点,有效治疗和消除媒介传播的寄生虫病打开了一扇新的窗口。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Promising Role of Wolbachia as Anti-parasitic Drug Target and Eco-Friendly Biocontrol Agent.

Background: Wolbachia is the most common endosymbiotic bacteria in insectborne parasites and it is the most common reproductive parasite in the world. Wolbachia has been found worldwide in numerous arthropod and parasite species, including insects, terrestrial isopods, spiders, mites and filarial nematodes. There is a complicated relationship between Wolbachia and its hosts and in some cases, they create a mutual relationship instead of a parasitic relationship. Some species are not able to reproduce in the absence of infection with Wolbachia. Thus, the use of existing strains of Wolbachia bacteria offers a potential strategy for the control of the population of mosquitoes and other pests and diseases.

Methods: We searched ten databases and reviewed published papers regarding the role of Wolbachia as a promising drug target and emerging biological control agents of parasitic diseases between 1996 and 2017 (22 years) were considered eligible. Also, in the current study several patents (WO008652), (US7723062), and (US 0345249 A1) were reviewed.

Results: Endosymbiotic Wolbachia bacteria, which are inherited from mothers, is transmitted to mosquitoes and interferes with pathogen transmission. They can change the reproduction of their host. Wolbachia is transmitted through the cytoplasm of eggs and have evolved different mechanisms for manipulating the reproduction of its hosts, including the induction of reproductive incompatibility, parthenogenesis, and feminization. The extensive effects of Wolbachia on reproduction and host fitness have made Wolbachia the issue of growing attention as a potential biocontrol agent.

Conclusion: Wolbachia has opened a new window to design a costly, potent and ecofriendly drug target for effective treatment and elimination of vector-borne parasitic diseases.

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来源期刊
Recent patents on anti-infective drug discovery
Recent patents on anti-infective drug discovery Medicine-Pharmacology (medical)
CiteScore
2.40
自引率
0.00%
发文量
1
期刊介绍: Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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