下丘脑神经元分子、网络和内分泌特征的统一分类。

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-02-08 DOI:10.1146/annurev-neuro-070918-050414
Roman A Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
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引用次数: 27

摘要

外周内分泌输出依赖于来自下丘脑的直接或前馈多阶指令。内分泌反应的有效编码是由多种神经元细胞共存于嵌入的下丘脑核中,并通过广泛的突触连接进行交流而成为可能的。虽然下丘脑神经元的一般解剖和神经化学特征在过去的几十年里被描述,但它们还没有与最近发现的分子分类器和神经遗传功能测定相协调。通过询问大细胞和副细胞多巴胺、GABA、谷氨酸和表型混合神经元,我们整合了分子、细胞、网络和内分泌输出水平的现有信息,提出了一个下丘脑神经元综合分类的框架。同时,我们挑选出假定的神经元亚类,未来的研究可以填补现有的知识空白,通过下丘脑的功能决定分子标记来合理化细胞多样性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons.

Peripheral endocrine output relies on either direct or feed-forward multi-order command from the hypothalamus. Efficient coding of endocrine responses is made possible by the many neuronal cell types that coexist in intercalated hypothalamic nuclei and communicate through extensive synaptic connectivity. Although general anatomical and neurochemical features of hypothalamic neurons were described during the past decades, they have yet to be reconciled with recently discovered molecular classifiers and neurogenetic function determination. By interrogating magnocellular as well as parvocellular dopamine, GABA, glutamate, and phenotypically mixed neurons, we integrate available information at the molecular, cellular, network, and endocrine output levels to propose a framework for the comprehensive classification of hypothalamic neurons. Simultaneously, we single out putative neuronal subclasses for which future research can fill in existing gaps of knowledge to rationalize cellular diversity through function-determinant molecular marks in the hypothalamus.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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