[艾塞那肽对青蛙和大鼠血糖和肾脏水离子排泄影响的差异]。

A V Kutina, A S Marina, Yu V Natochin
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引用次数: 0

摘要

本研究旨在比较胰高血糖素样肽-1 (GLP-1)模拟艾塞那肽对不同肾小管近端重吸收水平动物——大鼠(Rattus norvegicus)和青蛙(Rana temporaria)体内葡萄糖和水盐稳态的影响。葡萄糖耐量试验表明,艾塞那肽能促进大鼠血糖快速恢复,而在青蛙体内则能延缓这一过程。在水负荷大鼠中,艾塞那肽基本上增加了无溶质水的清除,并增强了速尿治疗大鼠的尿钠。在水利尿和速尿治疗下,艾塞那肽对青蛙的尿流率、尿钠排泄和无溶质水清除率没有影响。这表明,GLP- 1参与哺乳动物水盐稳态的调节应该在关键的进化转化-肾小球滤过率和近端小管重吸收增加-之前发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[DIFFERENCES OF EXENATIDE EFFECTS ON GLYCEMIA AND RENAL WATER AND ION EXCRETION IN FROGS AND RATS].

The aim of the present study was to compare effects of glucagon-like peptide-1 (GLP-1) mimetic exenatide on glucose and water-salt homeostasis in animals with different level of renal tubular proximal reabsorption - rats (Rattus norvegicus) and frogs (Rana temporaria). Following glucose tolerance test, in rats exenatide promoted rapid recovery of normoglycemia, whereas in frogs delayed this process. In water-loaded rats exenatide essentially augmented solute-free water clearance and enhanced natriuresis in furosemide-treated rats.-In frogs exenatide did not alter urinary flow rate, urinary sodium excretion and solute-free water clearance under water diuresis and furosemide treatment. It is suggested that the invol- vement of GLP- 1 in regulation of water-salt homeostasis in mammals should be preceded by key evoluti- onary transformation - increase in glomerular filtration rate and proximal tubular reabsorption.

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