[游离形式的d -氨基酸作为一种新的生物活性物质:生理功能和参与人体病理生理]。

Masumi Katane, Hiroshi Homma
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引用次数: 0

摘要

长期以来人们一直认为。d -氨基酸要么是非自然的异构体,要么是实验室的人工产物,氨基酸的重要功能只有l -氨基酸才能发挥作用。然而,最近的研究表明,多种d -氨基酸存在于包括哺乳动物在内的各种生物体中,并且它们在体内的生理功能中起着重要作用。本文综述了游离d -氨基酸在组织和细胞中的表达和定位、生物和生理活性、生物合成、细胞运输和降解等方面的最新研究进展。从人体病理生理学的角度,游离d -氨基酸与疾病的可能相关性也被描述。(审查)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The Free Form of D-Amino Acids As a Novel Bioactive Substance: Physiological Functions and Involvement in Human Pathophysiology].

It was long considered that.D-amino acids were either unnatural isomers or laboratorial artifacts, and that the important functions of amino acids were exerted only by L-amino acids. However, recent investigations have shown that a variety of D-amino acids are present in various organisms, including mammals, and that they play important roles in physiological functions in the body. Here, we present an overview of recent studies of free D-amino acids, focusing on the expression and localization in tissues and cells, biological and physiological activities, biosynthesis, cellular transport, and degradation. From the point of view of human pathophysiology, the possible relevance of free D-amino acids to disease is also described. [Review].

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