Uttara Partap, Sophie H Allcock, Edyth Parker, Deepti Gurdasani, Elizabeth H Young, Manjinder S Sandhu
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Most studies did not appropriately account for confounding by indication for antibiotic use. Overall, we found no consistent and conclusive evidence of associations between early life antibiotic use and later child body mass [minimum overall adjusted odds ratio (aOR) reported: 1.01, 95% confidence interval (95% CI) 0.98-1.04, <i>N</i> = 2 60 556; maximum overall aOR reported: 2.56, 95% CI 1.36-4.79, <i>N</i> = 616], with no clinically meaningful increases in weight reported (maximum increase: 1.50 kg at 15 years of age). Notable methodological differences between studies, including variable measures of association and inclusion of confounders, limited more comprehensive interpretations.</p><p><strong>Conclusions: </strong>Evidence to date is insufficient to indicate that antibiotic use is an important risk factor for child obesity, or leads to clinically important differences in weight. Further comparable studies using routine clinical data may help clarify this association.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":"e18"},"PeriodicalIF":1.1000,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2018.16","citationCount":"6","resultStr":"{\"title\":\"Association between early life antibiotic use and childhood overweight and obesity: a narrative review.\",\"authors\":\"Uttara Partap, Sophie H Allcock, Edyth Parker, Deepti Gurdasani, Elizabeth H Young, Manjinder S Sandhu\",\"doi\":\"10.1017/gheg.2018.16\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Recent research implicates antibiotic use as a potential contributor to child obesity risk. In this narrative review, we examine current observational evidence on the relation between antibiotic use in early childhood and subsequent measures of child body mass.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science and the Cochrane Library to identify studies that assessed antibiotic exposure before 3 years of age and subsequent measures of body mass or risk of overweight or obesity in childhood.</p><p><strong>Results: </strong>We identified 13 studies published before October 2017, based on a total of 6 81 332 individuals, which examined the relation between early life antibiotic exposure and measures of child body mass. Most studies did not appropriately account for confounding by indication for antibiotic use. 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引用次数: 6
摘要
背景:最近的研究表明抗生素的使用是儿童肥胖风险的潜在因素。在这篇叙述性综述中,我们研究了目前关于儿童早期抗生素使用与随后儿童体重测量之间关系的观察证据。方法:我们检索了PubMed, Web of Science和Cochrane Library,以确定评估3岁前抗生素暴露和随后的体重测量或儿童超重或肥胖风险的研究。结果:我们确定了2017年10月之前发表的13项研究,这些研究基于总共681 332名个体,研究了生命早期抗生素暴露与儿童体重测量之间的关系。大多数研究没有适当地解释抗生素使用指征的混淆。总体而言,我们没有发现生命早期抗生素使用与后期儿童体重之间存在一致和确凿的证据[报道的最小总体调整优势比(aOR): 1.01, 95%可信区间(95% CI) 0.98-1.04, N = 2 60 556;报告的最大总体aOR: 2.56, 95% CI 1.36-4.79, N = 616],未报告有临床意义的体重增加(15岁时最大增加:1.50 kg)。研究之间显著的方法差异,包括关联的变量测量和混杂因素的纳入,限制了更全面的解释。结论:迄今为止的证据不足以表明抗生素的使用是儿童肥胖的重要危险因素,或导致临床上重要的体重差异。使用常规临床数据的进一步可比研究可能有助于澄清这种关联。
Association between early life antibiotic use and childhood overweight and obesity: a narrative review.
Background: Recent research implicates antibiotic use as a potential contributor to child obesity risk. In this narrative review, we examine current observational evidence on the relation between antibiotic use in early childhood and subsequent measures of child body mass.
Methods: We searched PubMed, Web of Science and the Cochrane Library to identify studies that assessed antibiotic exposure before 3 years of age and subsequent measures of body mass or risk of overweight or obesity in childhood.
Results: We identified 13 studies published before October 2017, based on a total of 6 81 332 individuals, which examined the relation between early life antibiotic exposure and measures of child body mass. Most studies did not appropriately account for confounding by indication for antibiotic use. Overall, we found no consistent and conclusive evidence of associations between early life antibiotic use and later child body mass [minimum overall adjusted odds ratio (aOR) reported: 1.01, 95% confidence interval (95% CI) 0.98-1.04, N = 2 60 556; maximum overall aOR reported: 2.56, 95% CI 1.36-4.79, N = 616], with no clinically meaningful increases in weight reported (maximum increase: 1.50 kg at 15 years of age). Notable methodological differences between studies, including variable measures of association and inclusion of confounders, limited more comprehensive interpretations.
Conclusions: Evidence to date is insufficient to indicate that antibiotic use is an important risk factor for child obesity, or leads to clinically important differences in weight. Further comparable studies using routine clinical data may help clarify this association.