使用连续血糖监测仪对未接受胰岛素治疗的 2 型糖尿病患者进行斋月禁食期间血糖变异性的初步增加。

IF 1.8 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Nesreen Aldawi, Gassan Darwiche, Salah Abusnana, Murtada Elbagir, Targ Elgzyri
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引用次数: 0

摘要

目前还没有研究使用连续血糖监测仪(CGM)评估 2 型糖尿病患者在斋月禁食不同时期的血糖变异性。本研究考察了斋月禁食对未接受胰岛素治疗的 2 型糖尿病患者斋月早期、斋月晚期和斋月后期间质葡萄糖 (IG) 变异性的影响,并与斋月前进行了比较。参与者在斋月开始前 2 或 3 天连接了 CGM 系统,并在斋月的第三或第四天将其移除。CGM 监测共持续 6 天。第二次 CGM 测试从斋月的第 27 或 28 天开始,到斋月后的第 4 或 5 天结束。第一次 CGM 记录分为斋月前和斋月初期 CGM,第二次记录分为斋月后期和斋月后期 CGM。每次就诊时,都会测量血压、体重和腰围,并采集空腹血样以检测 HbA1c 和血浆葡萄糖。所有患者在斋月前都接受了建议的斋月教育。前瞻性纳入了 33 名患者(平均年龄为 55.0 ± 9.8 岁,73% 为男性)。以血糖偏移平均振幅(MAGE)估算的 IG 变异性在斋月早期比斋月前显著增加(P = 0.006),但在斋月晚期和斋月后的记录日则没有显著增加。只有服用两种以上抗糖尿病药物的患者(16 人,P = 0.019)和服用磺脲类药物的患者(14 人,P = 0.003)的 MAGE 在拉马丹早期有明显增加。变异系数、范围内时间、高血糖时间或低血糖时间均无明显变化。与斋月前不禁食相比,未接受胰岛素治疗的 2 型糖尿病患者禁食斋月期间的血糖变异性或低血糖时间与斋月前不禁食相比,除最初的血糖变异性增加外,并无任何明显变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Initial increase in glucose variability during Ramadan fasting in non-insulin-treated patients with diabetes type 2 using continuous glucose monitoring.

Initial increase in glucose variability during Ramadan fasting in non-insulin-treated patients with diabetes type 2 using continuous glucose monitoring.

There are no studies evaluating the glucose variability in different periods of Ramadan fasting in patients with type 2 diabetes using continuous glucose monitoring (CGM). This study examined the effect of Ramadan fasting on interstitial glucose (IG) variability in early,- late-, and post-Ramadan compared to pre-Ramadan days in non-insulin-treated type 2 diabetes patients. Participants had a CGM system connected 2 or 3 days before Ramadan start, which was removed on the third or fourth day of Ramadan. CGM performance continued for a total of 6 days. A second CGM performance started on the 27th or 28th day of Ramadan and ended on the 4th or 5th post-Ramadan day. First, CGM recordings were divided into pre-Ramadan and early-Ramadan CGM, and second recordings into late-Ramadan and post-Ramadan. At each visit, blood pressure, body weight, and waist circumference were measured, and fasting blood samples were collected for HbA1c and plasma glucose. All patients received recommended Ramadan education before Ramadan. Thirty-three patients (mean age 55.0 ± 9.8 years, 73% males) were prospectively included. IG variability, estimated as mean amplitude of glycaemic excursions (MAGE), increased significantly in early-Ramadan compared to pre-Ramadan (P = 0.006) but not in late-Ramadan and post-Ramadan recording days. Only patients on >2 anti-diabetic drugs (n = 16, P = 0.019) and those on sulphonylureas (n = 14, P = 0.003) showed significant increase in MAGE in early-Ramadan. No significant changes were seen in coefficient of variation, time in range, time in hyperglycaemia, or time in hypoglycaemia. Except for an initial increase in glucose variability, fasting Ramadan for patients with non-insulin-treated type 2 diabetes did not cause any significant changes in glucose variability or time in hypoglycaemia during CGM recording days compared to non-fasting pre-Ramadan period.

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来源期刊
Libyan Journal of Medicine
Libyan Journal of Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.20%
发文量
20
审稿时长
>12 weeks
期刊介绍: Libyan Journal of Medicine (LJM) is a peer-reviewed, Open Access, international medical journal aiming to promote heath and health education by publishing high-quality medical research in the different disciplines of medicine. LJM was founded in 2006 by a group of enthusiastic Libyan medical scientists who looked at the contribution of Libyan publications to the international medical literature and saw that a publication outlet was missing. To fill this gap they launched LJM as a tool for transferring current medical knowledge to and from colleagues in developing countries, particularly African countries, as well as internationally.The journal is still led by a group of Libyan physicians inside and outside Libya, but it also enjoys support and recognition from the international medical community.
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