评估健康儿科人群中的脑源性神经营养因子和骨生成素。

Q3 Medicine
Journal of Circulating Biomarkers Pub Date : 2018-10-18 eCollection Date: 2018-01-01 DOI:10.1177/1849454418806136
Joshua D Chew, Larry Markham, Holly M Smith, Yan Ru Su, Kelsey Tomasek, James C Slaughter, Douglas Sawyer, Jonathan H Soslow
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引用次数: 0

摘要

在临床实践中,生物标记物通常用于非侵入性的疾病过程识别或监测,以及药物开发的替代终点。有关儿童生物标志物的数据非常缺乏。随着越来越多的研究开始将无创生物标志物应用于儿科人群,了解健康儿科人群的生物标志物水平至关重要。脑源性神经营养因子(BDNF)在神经元存活和可塑性方面发挥作用,并与运动能力和炎症性疾病过程有关。骨营养素(OPN)在炎症中起调节作用,可能是心血管疾病过程、心室重塑和骨骼肌再生的临床有用生物标志物。本研究介绍了我们对一组健康儿科患者的初步经验,并试图提供 BDNF 和 OPN 的正常值,以及与年龄、性别、心血管和体能测量的相关性。使用酶联免疫吸附测定法对 33 名健康儿科受试者的血清 BDNF 和血浆 OPN 进行了测定。受试者接受了完整的心脏评估,包括超声心动图、运动负荷测试和健康风险评估。血清BDNF的第5-95百分位数为5.63-37.86纳克/毫升,血浆OPN的第5-95百分位数为4.9-164.9纳克/毫升。血浆 OPN 与每周运动天数相关(r = 0.46,p = 0.008)。其他相关性均不显著。这项研究提供了儿童血清 BDNF 和血浆 OPN 的初步数据,并开始探索 BDNF 和 OPN 与儿童心血管健康和体能的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Assessment of brain-derived neurotrophic factor and osteopontin in a healthy pediatric population.

Assessment of brain-derived neurotrophic factor and osteopontin in a healthy pediatric population.

Assessment of brain-derived neurotrophic factor and osteopontin in a healthy pediatric population.

Assessment of brain-derived neurotrophic factor and osteopontin in a healthy pediatric population.

Biomarkers are routinely used for noninvasive identification or monitoring of disease processes in clinical practice, as well as surrogate end points for drug development. There is a significant lack of data regarding biomarkers in children. An understanding of biomarker levels in a healthy pediatric cohort is essential as more studies begin to apply noninvasive biomarkers to pediatric populations. Brain-derived neurotrophic factor (BDNF) functions in neuronal survival and plasticity and is associated with exercise capacity and inflammatory disease processes. Osteopontin (OPN) plays a regulatory role in inflammation and may be a clinically useful biomarker of cardiovascular disease processes, ventricular remodeling, and skeletal muscle regeneration. This study describes our initial experience with a cohort of healthy pediatric patients and seeks to provide normal values of BDNF and OPN with correlation to age, gender, and cardiovascular and fitness measures. Serum BDNF and plasma OPN were measured using enzyme-linked immunosorbent assay in 33 healthy pediatric subjects. Subjects underwent complete cardiac evaluation, including echocardiography, exercise stress testing, and health risk assessment. The 5th-95th percentile was 5.63-37.86 ng/ml for serum BDNF and 4.9-164.9 ng/ml for plasma OPN. Plasma OPN correlated with number of days of exercise per week (r = 0.46, p = 0.008). No other correlations were significant. This study provides the initial data on serum BDNF and plasma OPN in children and begins to explore the relationships of BDNF and OPN to cardiovascular health and fitness in the pediatric population.

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来源期刊
Journal of Circulating Biomarkers
Journal of Circulating Biomarkers Medicine-Biochemistry (medical)
CiteScore
3.20
自引率
0.00%
发文量
9
审稿时长
8 weeks
期刊介绍: Journal of Circulating Biomarkers is an international, peer-reviewed, open access scientific journal focusing on all aspects of the rapidly growing field of circulating blood-based biomarkers and diagnostics using circulating protein and lipid markers, circulating tumor cells (CTC), circulating cell-free DNA (cfDNA) and extracellular vesicles, including exosomes, microvesicles, microparticles, ectosomes and apoptotic bodies. The journal publishes high-impact articles that deal with all fields related to circulating biomarkers and diagnostics, ranging from basic science to translational and clinical applications. Papers from a wide variety of disciplines are welcome; interdisciplinary studies are especially suitable for this journal. Included within the scope are a broad array of specialties including (but not limited to) cancer, immunology, neurology, metabolic diseases, cardiovascular medicine, regenerative medicine, nosology, physiology, pathology, technological applications in diagnostics, therapeutics, vaccine, drug delivery, regenerative medicine, drug development and clinical trials. The journal also hosts reviews, perspectives and news on specific topics.
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