出生时维生素D水平与极低出生体重儿呼吸道疾病之间的关系。

Korean Journal of Pediatrics Pub Date : 2019-05-01 Epub Date: 2018-10-24 DOI:10.3345/kjp.2018.06632
Ian Kim, Sung Shin Kim, Jee In Song, Seock Hwa Yoon, Ga Young Park, Yong-Wha Lee
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引用次数: 30

摘要

目的:本研究旨在评估极低出生体重儿(VLBWIs)出生时的维生素D状况。方法:回顾性研究于2013年11月至2017年11月在顺天香大学富川医院进行。我们收集了230名vlbwi在出生第一天的血液样本和呼吸系统发病率数据。转移到其他医院的患者(n=19),在孕龄36周前死亡的患者(n=18),或出生后未立即采集血液样本的患者(n=5)被排除在外。最终,188名患者入组。比较不同维生素D水平的VLBWIs在人口统计学特征、孕产妇疾病、呼吸系统发病率和其他新生儿疾病方面的差异。结果:25-羟基维生素D (25(OH)D)测定血清维生素D平均水平为13.4±9.3 ng/mL。结论:本研究早产儿出生时维生素D缺乏症发生率为79.8%。维生素D水平低与呼吸道疾病有关,但确切的机制尚不清楚。需要进一步研究维生素D水平与新生儿发病率之间的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants.

Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants.

Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants.
Purpose This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs: <1,500 g) and to determine the association between vitamin D level and respiratory morbidity. Methods A retrospective study was conducted at Soonchunhyang University Bucheon Hospital between November 2013 and November 2017. We collected blood samples and data on respiratory morbidity from 230 VLBWIs on the first day of life. Patients who were transferred to other hospitals (n=19), died before 36 weeks of gestational age (n=18), or whose blood samples were not collected immediately after birth (n=5) were excluded. Finally, 188 patients were enrolled. VLBWIs with different vitamin D levels were compared with respect to demographic features, maternal diseases, respiratory morbidities, and other neonatal diseases. Results The mean serum vitamin D level, as measured by 25-hydroxyvitamin D (25(OH)D), was 13.4± 9.3 ng/mL. The incidence of vitamin D deficiency (<20 ng/mL) was 79.8%, and 44.1% of preterm infants had severe vitamin D deficiency (<10 ng/mL). Logistic analysis shows that a low serum 25(OH)D level (<20 ng/mL) was a risk factor for respiratory distress syndrome (odds ratio [OR], 4.32; P=0.010) and bronchopulmonary dysplasia (OR, 4.11; P=0.035). Conclusion The results showed that 79.8% of preterm infants in this study had vitamin D deficiency at birth. Low vitamin D status was associated with respiratory morbidity, but the exact mechanism was unknown. Additional studies on the association between vitamin D level and neonatal morbidity are required.
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来源期刊
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审稿时长
12 weeks
期刊介绍: Korean J Pediatr covers clinical and research works relevant to all aspects of child healthcare. The journal aims to serve pediatricians through the prompt publication of significant advances in any field of pediatrics and to rapidly disseminate recently updated knowledge to the public. Additionally, it will initiate dynamic, international, academic discussions concerning the major topics related to pediatrics. Manuscripts are categorized as review articles, original articles, and case reports. Areas of specific interest include: Growth and development, Neonatology, Pediatric neurology, Pediatric nephrology, Pediatric endocrinology, Pediatric cardiology, Pediatric allergy, Pediatric pulmonology, Pediatric infectious diseases, Pediatric immunology, Pediatric hemato-oncology, Pediatric gastroenterology, Nutrition, Human genetics, Metabolic diseases, Adolescence medicine, General pediatrics.
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