粘蛋白及其在塑造粘液屏障功能方面的作用。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
C E Wagner, K M Wheeler, K Ribbeck
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引用次数: 0

摘要

我们回顾了目前对粘液的主要固体成分--糖蛋白粘蛋白的结构如何产生粘液的机械和生化特性的理解,而粘液的机械和生化特性正是粘液发挥各种生理作用所必需的。润滑等宏观过程要求粘液具有一定的硬度和可纺性,这是由粘蛋白网络的结构特征决定的,包括交联的特性和密度以及糖基化程度。在微观尺度上,这些特征同样会影响小颗粒所经历的机械环境,并在建立基于相互作用的过滤器方面发挥关键作用。最后,粘蛋白聚糖是调节微生物相互作用的关键,可作为粘附的受体结合位点、营养源和环境信号。最后,我们讨论了如何将这些结构原理用于设计合成粘蛋白仿生材料,并对这一领域未来的工作方向提出了建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mucins and Their Role in Shaping the Functions of Mucus Barriers.

We review what is currently understood about how the structure of the primary solid component of mucus, the glycoprotein mucin, gives rise to the mechanical and biochemical properties of mucus that are required for it to perform its diverse physiological roles. Macroscale processes such as lubrication require mucus of a certain stiffness and spinnability, which are set by structural features of the mucin network, including the identity and density of cross-links and the degree of glycosylation. At the microscale, these same features affect the mechanical environment experienced by small particles and play a crucial role in establishing an interaction-based filter. Finally, mucin glycans are critical for regulating microbial interactions, serving as receptor binding sites for adhesion, as nutrient sources, and as environmental signals. We conclude by discussing how these structural principles can be used in the design of synthetic mucin-mimetic materials and provide suggestions for directions of future work in this field.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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