细胞移植在小鼠肝损伤修复中的作用

Ontogenez Pub Date : 2017-01-01
E S Korobko, E A Suprunenko, A V Vasil’ev
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引用次数: 0

摘要

比较人肝癌细胞hepg2和异体脂肪组织间充质间质细胞(AT MSCs)两种移植方法对小鼠肝损伤的修复效果,以选择最有效的移植方法。脾内细胞移植比腹腔内给药更有优势。结果发现,在相似的移植条件下,肝组织中检测到的AT MSCs数量少于人肝癌细胞HepG2;揭示了这些类型的细胞在肝脏中定位的差异。我们发现AT MSCs移植后肝组织纤维化程度有降低的趋势,且经白细胞介素-6预处理的AT MSCs移植后肝组织纤维化程度有更大的降低趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Efficiency of Cell Transplantation in Repair of Mouse Liver Damage].

The effectiveness of two transplantation methods of human hepatocellular carcinoma cells HepG2 and allogeneic mesenchymal stromal cells of adipose tissue (AT MSCs) into mice was compared in order to select the most effective for liver damage repair. Considerable advantage of cell transplantation into the spleen compared with intraperitoneal administration was shown. It is found that, under similar conditions of transplantation, AT MSCs are detected in liver tissue in smaller quantities than human hepatocellular carcinoma cells HepG2; differences in cell localization of these types of cells in the liver are revealed. A tendency to decrease in the degree of fibrotic changes in liver tissue after transplantation of AT MSCs and to a greater extent after transplantation of AT MSCs, pretreated with interleukin-6, was traced.

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