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引用次数: 3
摘要
Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor E2-related factor 2 (NRF2L2，最广为人知的是NRF2)通路在细胞对氧化应激反应的调控中起关键的细胞保护作用。我们报道NRF2调节microRNA-125B和microRNA-29B在急性髓系白血病中的表达。在白血病中对microRNA的调节现在可以添加到NRF2不断增长的促生存功能列表中。
Targeting the KEAP1/NRF2 pathway to manipulate the expression of oncogenic and oncosuppressive miRNAs in human leukemia.
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor E2-related factor 2 (NRF2L2, best known as NRF2) pathway plays a pivotal cytoprotective role in the regulation of cellular responses to oxidative stress. We report that NRF2 modulates the expression of microRNA-125B and microRNA-29B in acute myeloid leukemia. The regulation of microRNA in leukemia can now be added to the growing list of prosurvival functions of NRF2.
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