Mengjie Hu, Gulimiran Alitongbieke, Ying Su, Hu Zhou, Xiao-Kun Zhang
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Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy.
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.
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