{"title":"自噬相关-5 (Atg5)对外泌体产生和转移的自噬非依赖性作用。","authors":"Huishan Guo, Remy Sadoul, Derrick Gibbings","doi":"10.1080/23723556.2018.1445941","DOIUrl":null,"url":null,"abstract":"<p><p>Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"e1445941"},"PeriodicalIF":0.0000,"publicationDate":"2018-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2018.1445941","citationCount":"12","resultStr":"{\"title\":\"Autophagy-independent effects of autophagy-related-5 (Atg5) on exosome production and metastasis.\",\"authors\":\"Huishan Guo, Remy Sadoul, Derrick Gibbings\",\"doi\":\"10.1080/23723556.2018.1445941\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.</p>\",\"PeriodicalId\":520710,\"journal\":{\"name\":\"Molecular & cellular oncology\",\"volume\":\" \",\"pages\":\"e1445941\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/23723556.2018.1445941\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & cellular oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23723556.2018.1445941\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & cellular oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23723556.2018.1445941","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
摘要
自噬相关-5 (autophagy -related-5, Atg5)和自噬相关-16- like -1 (autophagy - 16l1, Atg16L1)通常参与自噬。最近的研究表明，除此之外，它们还通过调节晚期内体的酸化来控制称为外泌体的细胞外囊泡的产生。atg5介导的外泌体的产生增加了乳腺癌细胞的迁移和转移，这表明外泌体可能具有自噬的某些功能。
Autophagy-independent effects of autophagy-related-5 (Atg5) on exosome production and metastasis.
Autophagy-related-5 (Atg5) and Autophagy-related-16-Like-1 (Atg16L1) canonically participate in autophagy. Recent research demonstrates that apart from this, they also control production of extracellular vesicles called exosomes by regulating acidification of late endosomes. Atg5-mediated exosome production increased migration and metastasis of breast cancer cells suggesting exosomes may perform some functions ascribed to autophagy.
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