组蛋白变体macroH2A1是剪接调节的基因组完整性和肿瘤生长的看护者。

Molecular & cellular oncology Pub Date : 2018-04-04 eCollection Date: 2018-01-01 DOI:10.1080/23723556.2018.1441629
Jeongkyu Kim, Philipp Oberdoerffer, Simran Khurana
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引用次数: 13

摘要

macroH2A1.2组蛋白变体促进了对复制应激的反应,与基因组维持和细胞生长有关。一个互斥剪接变体macroH2A1.1对DNA修复结果和增殖具有相反的影响。在这里,我们讨论剪接调节的macroH2A1染色质组织对细胞功能和恶性转化的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth.

The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth.

The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.

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