无创三维功率多普勒成像评估小鼠蛛网膜下腔出血模型急性脑血流改变。

IF 2.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Clinical and Experimental Pharmacology and Physiology Pub Date : 2019-01-01 DOI:10.1111/1440-1681.13035

Shuzo Yamamoto, Tatsushi Mutoh, Kazumasu Sasaki, Tomoko Mutoh, Yasuko Tatewaki, Yasuyuki Taki

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引用次数: 3

摘要

我们的目的是评估使用高频功率多普勒超声成像在小鼠蛛网膜下腔出血(SAH)模型中测量脑血流量(CBF)的无创方法的可行性。大脑中动脉区域脑容量内三维重建血流信号(%血管密度)与参考参数、颈动脉基线血流相关良好(r2 = 0.52, p2 = 0.74 P)

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Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage.

We aimed to evaluate the feasibility of a non-invasive method of cerebral blood flow (CBF) measurement using high-frequency power Doppler ultrasound imaging in a mouse model of subarachnoid haemorrhage (SAH). The 3-dimensionally (3D) reconstructed blood flow signals (%vascularity) within the brain volume of the middle cerebral artery territory correlated well with reference parameters, baseline carotid artery blood flow (r² = 0.52, P < 0.0001) and normalized CBF changes (r² = 0.74 P < 0.0001). These data suggest that the 3D power Doppler analysis may have the potential for reflecting real-time CBF changes during the acute phase of experimental SAH, which may be applicable to preclinical studies on early brain injury.

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来源期刊

Clinical and Experimental Pharmacology and Physiology PHARMACOLOGY & PHARMACY-PHYSIOLOGY

自引率

0.00%

发文量

128

期刊介绍： Clinical and Experimental Pharmacology and Physiology is an international journal founded in 1974 by Mike Rand, Austin Doyle, John Coghlan and Paul Korner. Our focus is new frontiers in physiology and pharmacology, emphasizing the translation of basic research to clinical practice. We publish original articles, invited reviews and our exciting, cutting-edge Frontiers-in-Research series’.