脂质体布比卡因与普通局麻药相比减少术后疼痛:一项随机对照试验的最新荟萃分析。

Q2 Medicine
Pain Research and Treatment Pub Date : 2018-07-15 eCollection Date: 2018-01-01 DOI:10.1155/2018/5710169
Mark C Kendall, Lucas Jorge Castro Alves, Gildasio De Oliveira
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引用次数: 32

摘要

目的:周围神经阻滞用于术后镇痛提高了阻滞成功率,但传统局麻药持续时间短,限制了镇痛效果。比较脂质体布比卡因与常规局部麻醉制剂(如普通布比卡因和罗哌卡因)的随机试验结果产生了相互矛盾的结果。本研究旨在系统回顾布比卡因脂质体在手术部位浸润与普通局麻布比卡因或罗哌卡因在手术患者中的镇痛效果。方法:遵循PRISMA声明指南。检索2012年1月至2017年9月美国国家医学图书馆PubMed数据库、Cochrane系统评价数据库、Embase和Google Scholar等电子数据库。在确定的1,612项记录中,9项随机对照试验涉及779名患者,符合数据提取和荟萃分析的条件。结果:与普通局麻药相比,脂质体布比卡因在术后24和48小时内并没有减轻术后休息时的疼痛。此外,与普通局麻药相比,脂质体布比卡因并没有减少术后24、48或72小时的阿片类药物消耗。与普通局麻药相比,布比卡因脂质体确实减少了术后恶心(P =结论:我们的研究结果表明,与普通局麻药相比,布比卡因脂质体在手术部位对接受外科手术的患者没有镇痛优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Liposome Bupivacaine Compared to Plain Local Anesthetics to Reduce Postsurgical Pain: An Updated Meta-Analysis of Randomized Controlled Trials.

Liposome Bupivacaine Compared to Plain Local Anesthetics to Reduce Postsurgical Pain: An Updated Meta-Analysis of Randomized Controlled Trials.

Liposome Bupivacaine Compared to Plain Local Anesthetics to Reduce Postsurgical Pain: An Updated Meta-Analysis of Randomized Controlled Trials.

Liposome Bupivacaine Compared to Plain Local Anesthetics to Reduce Postsurgical Pain: An Updated Meta-Analysis of Randomized Controlled Trials.

Objective: Peripheral nerve blocks for postoperative analgesia have improved block success, but analgesia efficacy has been limited by the short duration of traditional local anesthetics. The results of randomized trials comparing liposome bupivacaine with conventional local anesthetic formulations (e.g., plain bupivacaine and ropivacaine) have generated conflicting results. This study was conducted to systematically review the effectiveness of analgesic efficacy of liposome bupivacaine infiltration at the surgical site versus plain local anesthetic bupivacaine or ropivacaine in patients undergoing surgery.

Methods: PRISMA statement guidelines were followed. A search of electronic databases National Library of Medicine's PubMed database, Cochrane Database of Systematic Reviews, Embase, and Google Scholar from January 2012 to September 2017 was performed. Among the 1,612 records identified, 9 randomized controlled trials involving 779 patients were eligible for data extraction and meta-analysis.

Results: Liposome bupivacaine did not reduce postsurgical pain at rest compared to plain local anesthetics at 24 and 48 hours after surgery. Moreover, liposome bupivacaine did not reduce postoperative opioid consumption at 24, 48, or 72 hours when compared to plain local anesthetics. Liposome bupivacaine did reduce postoperative nausea when compared to plain local anesthetics (P =<0.3). There was no significant difference in hospital length of stay between study groups, the use of plain bupivacaine or ropivacaine, or among orthopedic or nonorthopedic procedures. No manifestations of local anesthetic toxicity were reported.

Conclusions: Our results suggest that liposome bupivacaine does not have an analgesic advantage when compared to plain local anesthetics at the surgical site for patients undergoing surgical procedures.

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来源期刊
Pain Research and Treatment
Pain Research and Treatment Medicine-Anesthesiology and Pain Medicine
CiteScore
3.60
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