{"title":"一种潜在的 Rho GEF 和 Rac GAP，用于间充质到上皮样转变过程中的 Rac 和 Rho 循环耦合。","authors":"Christopher P Toret, Andre Le Bivic","doi":"10.1080/21541248.2018.1502592","DOIUrl":null,"url":null,"abstract":"<p><p>The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP were identified as key, conserved regulators that link Rac and Rho during these transitions. The corresponding Rho GEF and Rac GAP remain hidden amongst the large family of GEF and GAP proteins. Identification of these regulators is essential to understand GTPase coordination during these transitions. Here we find two candidates based on the mammalian literature and use RNAi to explore the fly ortholog effects on the dorsal closure epidermis. RhoGEF64C and RhoGAP92B are strong contenders to couple Rac and Rho during mesenchymal-to-epithelial-like transitions.</p>","PeriodicalId":22139,"journal":{"name":"Small GTPases","volume":"12 1","pages":"13-19"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781753/pdf/KSGT_12_1502592.pdf","citationCount":"0","resultStr":"{\"title\":\"A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions.\",\"authors\":\"Christopher P Toret, Andre Le Bivic\",\"doi\":\"10.1080/21541248.2018.1502592\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP were identified as key, conserved regulators that link Rac and Rho during these transitions. The corresponding Rho GEF and Rac GAP remain hidden amongst the large family of GEF and GAP proteins. Identification of these regulators is essential to understand GTPase coordination during these transitions. Here we find two candidates based on the mammalian literature and use RNAi to explore the fly ortholog effects on the dorsal closure epidermis. RhoGEF64C and RhoGAP92B are strong contenders to couple Rac and Rho during mesenchymal-to-epithelial-like transitions.</p>\",\"PeriodicalId\":22139,\"journal\":{\"name\":\"Small GTPases\",\"volume\":\"12 1\",\"pages\":\"13-19\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781753/pdf/KSGT_12_1502592.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small GTPases\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21541248.2018.1502592\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/8/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small GTPases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21541248.2018.1502592","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/8/29 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
摘要
在后生动物的发育过程和疾病状态中，前缘到粘连蛋白的接触转换需要 Rac 和 Rho 通路的精细协调。最近，Rac GEF elmo-mbc复合物和Rho GAP RhoGAP19D被确认为在这些转换过程中连接Rac和Rho的关键保守调节因子。相应的 Rho GEF 和 Rac GAP 仍然隐藏在庞大的 GEF 和 GAP 蛋白家族中。鉴定这些调节因子对于了解这些转变过程中 GTPase 的协调至关重要。在这里，我们根据哺乳动物的文献找到了两个候选者，并使用 RNAi 来探索苍蝇直向同源物对背侧闭合表皮的影响。RhoGEF64C 和 RhoGAP92B 是在间充质向上皮样转变过程中连接 Rac 和 Rho 的有力竞争者。
A potential Rho GEF and Rac GAP for coupled Rac and Rho cycles during mesenchymal-to-epithelial-like transitions.
The leading edge-to-cadherin contact transitions that occur during metazoan developmental processes and disease states require fine coordination of Rac and Rho pathways. Recently the elmo-mbc complex, a Rac GEF and RhoGAP19D, a Rho GAP were identified as key, conserved regulators that link Rac and Rho during these transitions. The corresponding Rho GEF and Rac GAP remain hidden amongst the large family of GEF and GAP proteins. Identification of these regulators is essential to understand GTPase coordination during these transitions. Here we find two candidates based on the mammalian literature and use RNAi to explore the fly ortholog effects on the dorsal closure epidermis. RhoGEF64C and RhoGAP92B are strong contenders to couple Rac and Rho during mesenchymal-to-epithelial-like transitions.
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