MERS-CoV重组疫苗研究新进展

Huizhen Hu, Yuqing Shen
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引用次数: 0

摘要

中东呼吸综合征冠状病毒(MERS-Co - V)自发现以来引起了广泛关注,有效的MERS-Co - V疫苗设计成为当前研究的热点。因此,本文就MERS-Co - V重组疫苗的研究新进展,包括疫苗试验动物模型的选择与完善、重组亚单位疫苗的构建与优化、基于多种载体的重组活载体疫苗的尝试以及假病毒的优势等方面进行综述。最后,我们对MERS-Co - V重组疫苗的最新研究进展进行了总结,并对其未来在安全性和有效性验证方面的发展前景进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Novel Research Progress of the Recombinant Vaccine for MERS-CoV].

Respiratory syndrome coronavirus in the Middle East (MERS-Co V) has caused wide attention since it was discovered, and the design of effective vaccines for MERS-Co V becomes a hot area at present. Therefore, this review is aimed at novel research progress of the recombinant vaccine for MERS-Co V, including selection and improvement of animal model for vaccine test,construction and optimization of recombinant subunit vaccine, attempts at recombinant live vector vaccine based on varies of vectors, as well as the advantages of pseudovirus. In conclusion, we make a summary about the novel research progress of the recombinant vaccine for MERS-Co V and a promising prospect of its development in terms of both safety and effectiveness verification in the future will be demonstrated.

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