Ha Thi Thanh Pham, Markus Hengstschläger, Richard Moriggl
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A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia.
The somatic hot spot mutation STAT5BN642H was found in many T cell leukemia/lymphoma patients. We generated and analyzed a transgenic mouse model with hematopoietic STAT5BN642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
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