人类视觉皮层的发展及其临床意义。

IF 3.1 Q1 OPHTHALMOLOGY
Eye and Brain Pub Date : 2018-04-24 eCollection Date: 2018-01-01 DOI:10.2147/EB.S130893
Caitlin R Siu, Kathryn M Murphy
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引用次数: 0

摘要

初级视觉皮层(V1)是处理视觉信息的第一个皮层区域。V1 的正常发育取决于关键时期的双眼视觉,与年龄相关的视力丧失与 V1 的神经生物学变化有关。动物研究提供了有关 V1 神经生物学机制的重要细节,这些机制支持正常视觉或因视觉疾病而改变。然而,关于人类 V1 神经生物学机制的信息却很少。这种信息的匮乏阻碍了将生物启发疗法从临床前模型转化为有效的临床疗法。我们对人类 V1 进行了研究,以确定调节视觉感知和神经可塑性的神经生物学机制的表达特征。我们确定了人类 V1 的五个发育阶段,它们从婴儿期开始,贯穿整个生命周期。在此,我们描述了这些阶段,将它们与视觉和解剖学里程碑进行了比较,并讨论了转化治疗依赖于 V1 功能神经可塑性的视觉疾病的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The development of human visual cortex and clinical implications.

The development of human visual cortex and clinical implications.

The development of human visual cortex and clinical implications.

The development of human visual cortex and clinical implications.

The primary visual cortex (V1) is the first cortical area that processes visual information. Normal development of V1 depends on binocular vision during the critical period, and age-related losses of vision are linked with neurobiological changes in V1. Animal studies have provided important details about the neurobiological mechanisms in V1 that support normal vision or are changed by visual diseases. There is very little information, however, about those neurobiological mechanisms in human V1. That lack of information has hampered the translation of biologically inspired treatments from preclinical models to effective clinical treatments. We have studied human V1 to characterize the expression of neurobiological mechanisms that regulate visual perception and neuroplasticity. We have identified five stages of development for human V1 that start in infancy and continue across the life span. Here, we describe these stages, compare them with visual and anatomical milestones, and discuss implications for translating treatments for visual disorders that depend on neuroplasticity of V1 function.

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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
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