Malgorzata Krakowska-Stasiak, Dorota Cibor, Kinga Sałapa, Danuta Owczarek, Tomasz Mach
{"title":"体重对胃食管反流病患者临床症状及内镜改变的影响","authors":"Malgorzata Krakowska-Stasiak, Dorota Cibor, Kinga Sałapa, Danuta Owczarek, Tomasz Mach","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Gastroesophageal\nreflux disease (GERD) is connected\nwith body mass index (BMI) according\nto some recent studies. However, the\nlink between overweight and severity\nof GERD symptoms is still unclear.</p><p><strong>Objectives: </strong>The aim of our study\nis to assess the influence of BMI on\nclinical presentation and occurrence\nof inflammatory changes in the esophagus\nin patients with GERD.</p><p><strong>Material and methods: </strong>121 clinically\ndiagnosed GERD patients: 66 males\n(54.5%) and 55 females (45.5%), aged\n19 – 89 years were involved in the\nstudy. After the detailed anamnesis\nBMI was counted and gastroscopy\nwas performed. All individuals who\nagreed for upper endoscopy were\ndivided into three groups. 42 patients\n(34.7%) were classified as Non-Erosive\nReflux Disease (NERD), 53 patients\n(43.8%) were diagnosed with Erosive\nEsophagitis (EE), 11 patients (9.1%)\nwith Barrett’s esophagus (BE). Among\nEE group 34 patients were diagnosed\nwith grade A of esophagitis according\nto Los Angeles scale, 17 with grade B,\n2 with grade C and none with grade D.\nThe differences between groups were\nassessed using statistical analysis.</p><p><strong>Results: </strong>The mean age of patients\nwas 50.2±12.9 years and the mean\nBMI was 25.5±4.2 kg/m2. Patients with\nBE were older (61.2±12.0 years) than\nNERD (48.5±13.6 years); (p=0.028) and\nEE (50.4±11.4 years); (p=0.008). BE had\nhigher BMI (27.0±4.4 kg/m2) as compared\nto NERD (24.0±3.3 kg/m2); (p=0.022)\nand EE (24.4±3.1 kg/m2); (p=0.048). Hiatal\nhernia was more frequent in EE and\nBE (79.2% and 90.9%, respectively) as\ncompared to NERD (45.2%); (p<0.001).\nPatients EE and BE more frequently\ncomplained to heartburn (84.9% and\n72.7%, respectively) than patients with\nno mucosal injury (42.9%); (p<0.001).\nSleeping problems were encountered\nby patients with higher levels of BMI.</p><p><strong>Conclusion: </strong>This study demonstrates\nthat overweight predispose to\nesophageal inflammation and increase\nthe frequency of heartburn and sleep\nproblems in GERD patients.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of body weight on clinical symptoms and endoscopic changes in patients with gastroesophageal reflux disease.\",\"authors\":\"Malgorzata Krakowska-Stasiak, Dorota Cibor, Kinga Sałapa, Danuta Owczarek, Tomasz Mach\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Gastroesophageal\\nreflux disease (GERD) is connected\\nwith body mass index (BMI) according\\nto some recent studies. However, the\\nlink between overweight and severity\\nof GERD symptoms is still unclear.</p><p><strong>Objectives: </strong>The aim of our study\\nis to assess the influence of BMI on\\nclinical presentation and occurrence\\nof inflammatory changes in the esophagus\\nin patients with GERD.</p><p><strong>Material and methods: </strong>121 clinically\\ndiagnosed GERD patients: 66 males\\n(54.5%) and 55 females (45.5%), aged\\n19 – 89 years were involved in the\\nstudy. After the detailed anamnesis\\nBMI was counted and gastroscopy\\nwas performed. All individuals who\\nagreed for upper endoscopy were\\ndivided into three groups. 42 patients\\n(34.7%) were classified as Non-Erosive\\nReflux Disease (NERD), 53 patients\\n(43.8%) were diagnosed with Erosive\\nEsophagitis (EE), 11 patients (9.1%)\\nwith Barrett’s esophagus (BE). Among\\nEE group 34 patients were diagnosed\\nwith grade A of esophagitis according\\nto Los Angeles scale, 17 with grade B,\\n2 with grade C and none with grade D.\\nThe differences between groups were\\nassessed using statistical analysis.</p><p><strong>Results: </strong>The mean age of patients\\nwas 50.2±12.9 years and the mean\\nBMI was 25.5±4.2 kg/m2. Patients with\\nBE were older (61.2±12.0 years) than\\nNERD (48.5±13.6 years); (p=0.028) and\\nEE (50.4±11.4 years); (p=0.008). BE had\\nhigher BMI (27.0±4.4 kg/m2) as compared\\nto NERD (24.0±3.3 kg/m2); (p=0.022)\\nand EE (24.4±3.1 kg/m2); (p=0.048). Hiatal\\nhernia was more frequent in EE and\\nBE (79.2% and 90.9%, respectively) as\\ncompared to NERD (45.2%); (p<0.001).\\nPatients EE and BE more frequently\\ncomplained to heartburn (84.9% and\\n72.7%, respectively) than patients with\\nno mucosal injury (42.9%); (p<0.001).\\nSleeping problems were encountered\\nby patients with higher levels of BMI.</p><p><strong>Conclusion: </strong>This study demonstrates\\nthat overweight predispose to\\nesophageal inflammation and increase\\nthe frequency of heartburn and sleep\\nproblems in GERD patients.</p>\",\"PeriodicalId\":21148,\"journal\":{\"name\":\"Przeglad lekarski\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Przeglad lekarski\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad lekarski","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Impact of body weight on clinical symptoms and endoscopic changes in patients with gastroesophageal reflux disease.
Introduction: Gastroesophageal
reflux disease (GERD) is connected
with body mass index (BMI) according
to some recent studies. However, the
link between overweight and severity
of GERD symptoms is still unclear.
Objectives: The aim of our study
is to assess the influence of BMI on
clinical presentation and occurrence
of inflammatory changes in the esophagus
in patients with GERD.
Material and methods: 121 clinically
diagnosed GERD patients: 66 males
(54.5%) and 55 females (45.5%), aged
19 – 89 years were involved in the
study. After the detailed anamnesis
BMI was counted and gastroscopy
was performed. All individuals who
agreed for upper endoscopy were
divided into three groups. 42 patients
(34.7%) were classified as Non-Erosive
Reflux Disease (NERD), 53 patients
(43.8%) were diagnosed with Erosive
Esophagitis (EE), 11 patients (9.1%)
with Barrett’s esophagus (BE). Among
EE group 34 patients were diagnosed
with grade A of esophagitis according
to Los Angeles scale, 17 with grade B,
2 with grade C and none with grade D.
The differences between groups were
assessed using statistical analysis.
Results: The mean age of patients
was 50.2±12.9 years and the mean
BMI was 25.5±4.2 kg/m2. Patients with
BE were older (61.2±12.0 years) than
NERD (48.5±13.6 years); (p=0.028) and
EE (50.4±11.4 years); (p=0.008). BE had
higher BMI (27.0±4.4 kg/m2) as compared
to NERD (24.0±3.3 kg/m2); (p=0.022)
and EE (24.4±3.1 kg/m2); (p=0.048). Hiatal
hernia was more frequent in EE and
BE (79.2% and 90.9%, respectively) as
compared to NERD (45.2%); (p<0.001).
Patients EE and BE more frequently
complained to heartburn (84.9% and
72.7%, respectively) than patients with
no mucosal injury (42.9%); (p<0.001).
Sleeping problems were encountered
by patients with higher levels of BMI.
Conclusion: This study demonstrates
that overweight predispose to
esophageal inflammation and increase
the frequency of heartburn and sleep
problems in GERD patients.
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