不同理化性质壳聚糖衍生物的毒性和生物相容性分析。

E V Svirshchevskaya, A A Zubareva, A A Boiko, O A Shustova, M V Grechikhina, B Ts Shagdarova, V P Varlamov
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引用次数: 0

摘要

对不同乙酰化程度、分子量、电荷和疏水性的壳聚糖及其衍生物的毒性和血液相容性进行了比较研究。研究表明,只有带正电荷的壳聚糖衍生物才能激活血小板并抑制细胞增殖,而与乙酰化程度、分子质量和疏水性无关。壳聚糖季铵化在低取代度时降低毒性,在高取代度时突然增加毒性。带负电荷的壳聚糖衍生物无毒且与血液成分相容。壳聚糖及其衍生物的毒性是由它们的电荷和在中性pH下的溶解度决定的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Analysis of toxicity and biocompatibility of chitosan derivatives with different physico-chemical properties].

A comparative study of the toxicity and hemocompatibility of chitosan and its derivatives with different acetylation degrees, molecular masses, charges, and hydrophobicity has been performed. It has been shown that only positively charged chitosan derivatives activate platelets and suppress cell proliferation, regardless of the acetylation degree, molecular mass, and hydrophobicity. Chitosan quaternization decreases toxicity at a low degree of substitution and abruptly increases it at a high one. Negatively charged chitosan derivatives were nontoxic and compatible with blood components. It was concluded that the toxicity of chitosan and its derivatives is defined by their charge and solubility at a neutral pH.

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