{"title":"屏气试验在慢性心力衰竭患者外周血化学反射敏感性评价中的应用。","authors":"Nikita Trembach, Igor Zabolotskikh","doi":"10.2174/1874306401711010067","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The sensitivity of peripheral chemoreflex is a marker of the severity of heart failure and the prognosis of the outcome in these patients. The assessment of chemosensitivity in these patients remains an actual problem.</p><p><strong>Objective: </strong>The aim of the study was to explore the relationship between a Breath-Holding Test (BHT) and single-breath carbon dioxide test and to evaluate the reliability of both tests in patients with Heart Failure (HF).</p><p><strong>Method: </strong>The study was performed in 43 patients with chronic heart failure. All subjects underwent BHT and single-breath carbon dioxide (CB-CO<sub>2</sub>), the evaluation of both tests was repeated a month later. Relationship of two test was evaluated by correlation analysis. Reliability was assessed with calculation of Standard Error of Measurement (SEM), Coefficient of Variation (CV) and Intraclass Correlation Coefficient (ICC).</p><p><strong>Results: </strong>The duration of the breath-holding was inversely correlated to the result of CB-CO<sub>2</sub> test (r = -0.86 at first measurement and r = -0.79 after a month) The ICC was 0.87 (95%CI: 0.78-0.93) for SB-CO<sub>2</sub> test and 0,93 (95%CI: 0.88-0.96) for BHT, the CV was 24% for SB-CO<sub>2</sub> and 13% for BHT. SEM for SB-CO<sub>2</sub> test was 0.04 L / min / mmHg and limits of variation was 0.11 L / min / mmHg; SEM for BHT was 3.6 sec and limits of variation was10 sec.</p><p><strong>Conclusion: </strong>Breath-holding test is a reliable and safe method for assessing the sensitivity of peripheral chemoreflex to carbon dioxide in patients with heart failure.</p>","PeriodicalId":39127,"journal":{"name":"Open Respiratory Medicine Journal","volume":"11 ","pages":"67-74"},"PeriodicalIF":0.0000,"publicationDate":"2017-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750724/pdf/","citationCount":"8","resultStr":"{\"title\":\"Evaluation of Breath-Holding Test in Assessment of Peripheral Chemoreflex Sensitivity in Patients with Chronic Heart Failure.\",\"authors\":\"Nikita Trembach, Igor Zabolotskikh\",\"doi\":\"10.2174/1874306401711010067\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The sensitivity of peripheral chemoreflex is a marker of the severity of heart failure and the prognosis of the outcome in these patients. The assessment of chemosensitivity in these patients remains an actual problem.</p><p><strong>Objective: </strong>The aim of the study was to explore the relationship between a Breath-Holding Test (BHT) and single-breath carbon dioxide test and to evaluate the reliability of both tests in patients with Heart Failure (HF).</p><p><strong>Method: </strong>The study was performed in 43 patients with chronic heart failure. All subjects underwent BHT and single-breath carbon dioxide (CB-CO<sub>2</sub>), the evaluation of both tests was repeated a month later. Relationship of two test was evaluated by correlation analysis. Reliability was assessed with calculation of Standard Error of Measurement (SEM), Coefficient of Variation (CV) and Intraclass Correlation Coefficient (ICC).</p><p><strong>Results: </strong>The duration of the breath-holding was inversely correlated to the result of CB-CO<sub>2</sub> test (r = -0.86 at first measurement and r = -0.79 after a month) The ICC was 0.87 (95%CI: 0.78-0.93) for SB-CO<sub>2</sub> test and 0,93 (95%CI: 0.88-0.96) for BHT, the CV was 24% for SB-CO<sub>2</sub> and 13% for BHT. SEM for SB-CO<sub>2</sub> test was 0.04 L / min / mmHg and limits of variation was 0.11 L / min / mmHg; SEM for BHT was 3.6 sec and limits of variation was10 sec.</p><p><strong>Conclusion: </strong>Breath-holding test is a reliable and safe method for assessing the sensitivity of peripheral chemoreflex to carbon dioxide in patients with heart failure.</p>\",\"PeriodicalId\":39127,\"journal\":{\"name\":\"Open Respiratory Medicine Journal\",\"volume\":\"11 \",\"pages\":\"67-74\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-12-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750724/pdf/\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Open Respiratory Medicine Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1874306401711010067\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Open Respiratory Medicine Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1874306401711010067","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 8
摘要
背景:外周化疗反射的敏感性是心衰患者严重程度和预后的标志。评估这些患者的化疗敏感性仍然是一个实际问题。目的:本研究的目的是探讨屏气试验(BHT)和单次呼吸二氧化碳试验之间的关系，并评估这两种试验在心力衰竭(HF)患者中的可靠性。方法:对43例慢性心力衰竭患者进行研究。所有受试者均接受BHT和单次呼吸二氧化碳(CB-CO2)检测，1个月后重复两项测试的评估。通过相关分析评价两个检验的相关性。信度评估采用计量标准误差(SEM)、变异系数(CV)和类内相关系数(ICC)计算。结果:屏气时间与CB-CO2测试结果呈负相关(第一次测量时r = -0.86，一个月后r = -0.79)。SB-CO2测试的ICC为0.87 (95%CI: 0.78-0.93)， BHT的CV为0.93 (95%CI: 0.88-0.96)， SB-CO2测试的CV为24%，BHT的CV为13%。SB-CO2检测SEM为0.04 L / min / mmHg，变异限为0.11 L / min / mmHg;结论:屏气试验是评估心力衰竭患者外周化学反射对二氧化碳敏感性的一种可靠、安全的方法。
Evaluation of Breath-Holding Test in Assessment of Peripheral Chemoreflex Sensitivity in Patients with Chronic Heart Failure.
Background: The sensitivity of peripheral chemoreflex is a marker of the severity of heart failure and the prognosis of the outcome in these patients. The assessment of chemosensitivity in these patients remains an actual problem.
Objective: The aim of the study was to explore the relationship between a Breath-Holding Test (BHT) and single-breath carbon dioxide test and to evaluate the reliability of both tests in patients with Heart Failure (HF).
Method: The study was performed in 43 patients with chronic heart failure. All subjects underwent BHT and single-breath carbon dioxide (CB-CO2), the evaluation of both tests was repeated a month later. Relationship of two test was evaluated by correlation analysis. Reliability was assessed with calculation of Standard Error of Measurement (SEM), Coefficient of Variation (CV) and Intraclass Correlation Coefficient (ICC).
Results: The duration of the breath-holding was inversely correlated to the result of CB-CO2 test (r = -0.86 at first measurement and r = -0.79 after a month) The ICC was 0.87 (95%CI: 0.78-0.93) for SB-CO2 test and 0,93 (95%CI: 0.88-0.96) for BHT, the CV was 24% for SB-CO2 and 13% for BHT. SEM for SB-CO2 test was 0.04 L / min / mmHg and limits of variation was 0.11 L / min / mmHg; SEM for BHT was 3.6 sec and limits of variation was10 sec.
Conclusion: Breath-holding test is a reliable and safe method for assessing the sensitivity of peripheral chemoreflex to carbon dioxide in patients with heart failure.
期刊介绍：
The Open Respiratory Medicine Journal is an Open Access online journal, which publishes research articles, reviews/mini-reviews, letters and guest edited single topic issues in all important areas of experimental and clinical research in respiratory medicine. Topics covered include: -COPD- Occupational disorders, and the role of allergens and pollutants- Asthma- Allergy- Non-invasive ventilation- Therapeutic intervention- Lung cancer- Lung infections respiratory diseases- Therapeutic interventions- Adult and paediatric medicine- Cell biology. The Open Respiratory Medicine Journal, a peer reviewed journal, is an important and reliable source of current information on important recent developments in the field. The emphasis will be on publishing quality articles rapidly and making them freely available worldwide.
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