{"title":"RNA聚合酶I的激活和冬眠:独特基因的独特机制。","authors":"Carlos Fernández-Tornero","doi":"10.1080/21541264.2017.1416267","DOIUrl":null,"url":null,"abstract":"<p><p>In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA.</p>","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":" ","pages":"248-254"},"PeriodicalIF":3.6000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21541264.2017.1416267","citationCount":"26","resultStr":"{\"title\":\"RNA polymerase I activation and hibernation: unique mechanisms for unique genes.\",\"authors\":\"Carlos Fernández-Tornero\",\"doi\":\"10.1080/21541264.2017.1416267\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA.</p>\",\"PeriodicalId\":47009,\"journal\":{\"name\":\"Transcription-Austin\",\"volume\":\" \",\"pages\":\"248-254\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/21541264.2017.1416267\",\"citationCount\":\"26\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transcription-Austin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21541264.2017.1416267\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2018/1/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transcription-Austin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21541264.2017.1416267","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2018/1/26 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
RNA polymerase I activation and hibernation: unique mechanisms for unique genes.
In yeast, transcription of ribosomal DNA (rDNA) by RNA polymerase I (Pol I) is regulated by unique mechanisms acting at the level of the enzyme. Under stress situations such as starvation, Pol I hibernates through dimerization. When growth conditions are restored, dimer disassembly and Rrn3 binding drive enzyme activation and subsequent recruitment to rDNA.
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