2000年至2016年,在三级保健医院就诊的孟加拉国男性精液参数下降。

Nusrat Mahmud, Eshita Sharmin, Md Arif Mamun, Zayan Shamayeen, Natalie Rivadeneira, Roger Rochat, Akanksha Mehta
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引用次数: 5

摘要

简介:本研究的目的是分析孟加拉国男性精子参数的纵向变化。我们假设这一人群的精液参数有所下降。方法:我们回顾性分析了2000年1月至2016年6月在孟加拉国达卡一家不育诊所就诊的18-64岁男性的精液数据(n = 13,953),这些男性因一般精子质量或生育状况更新而就诊。排除资料不完整的样本(n = 143)。采用世界卫生组织正常标准和精液分析程序对其余13810例标本进行参数评估。精子浓度值缺失的样本(n = 6187)被排除在浓度分析之外。年龄和禁欲的持续时间在测试中被记录和调整。数据导入SAS®9.4统计软件。动力性参数采用单因素方差分析,原始浓度采用卡方检验。Logistic回归分析混杂因素对无精子症和原始浓度的影响,而中位数回归模型调整混杂因素对浓度、总活力和快速线性(RL)活力的影响。结果:年龄分布与年度参数变化(浓度、总运动性、RL运动性)显著相关[P < 0.0001]。到研究结束时,调整后的总运动性和RL运动性从最大值下降了20% (P < 0.0001)。原始浓度缺乏明确的趋势,不受调整的影响。在2000-2010年和2011-2016年的参与者中,无精子症增加了18%(优势比= 0.16[0.14-0.16])。结论:与假设一致,在该诊所就诊的孟加拉国男性精液参数(总活力和RL活力)下降,无精子症发生率增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Decline in semen parameters from 2000 to 2016 among Bangladeshi men attending a tertiary care hospital.

Decline in semen parameters from 2000 to 2016 among Bangladeshi men attending a tertiary care hospital.

Decline in semen parameters from 2000 to 2016 among Bangladeshi men attending a tertiary care hospital.

Decline in semen parameters from 2000 to 2016 among Bangladeshi men attending a tertiary care hospital.

Introduction: The objective of this study was to analyze longitudinal changes in sperm parameters of Bangladeshi men. We hypothesized that semen parameters declined for this population.

Methods: We retrospectively analyzed semen data from men aged 18-64 years who sought care for general sperm quality or updates on fertility status at an infertility clinic in Dhaka, Bangladesh, from January 2000 to June 2016 (n = 13,953). Samples with incomplete data were excluded (n = 143). The WHO normal criteria and semen analysis procedures were used to evaluate parameters of the remaining 13,810 specimens. Samples with missing values on sperm concentration (n = 6187) were excluded from concentration analyses. Age and duration of abstinence at testing were recorded and adjusted for. Data were imported into SAS® 9.4 statistical software. Temporal significance was investigated using one-way ANOVA for motility parameters and Chi-square test for raw concentration. Logistic regression analyzed the effects of confounders on azoospermia and raw concentration, while median regression modeling adjusted confounders for concentration, total motility, and rapid linear (RL) motility.

Results: Age distribution was significantly correlated with annual parameter changes (concentration, total motility, and RL motility [P < 0.0001]). Adjusted total motility and RL motility declined by 20% from their maximum values to end of the study (P < 0.0001). Raw concentration lacked clear trends and was unaffected by adjustment. Azoospermia increased by 18% between the 2000-2010 and 2011-2016 participants (odds ratio = 0.16 [0.14-0.16]).

Conclusion: In agreement with the hypothesis, Bangladeshi males attending this clinic have experienced decline in semen parameters (total motility and RL motility) and increased frequency of azoospermia.

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