利用18F-氟胆碱双时点PET/MRI对新诊断前列腺癌的定量测量和定性评估进行飞行时间和正则化重建的影响

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Spencer C Behr, Brett J Mollard, Jaewon Yang, Robert R Flavell, Randall A Hawkins, Youngho Seo
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引用次数: 0

摘要

正电子发射断层扫描/磁共振成像(PET/MRI)技术的最新进展大大改进了飞行时间(TOF)和正则化迭代 PET 重建正则化迭代重建(RIR)算法。我们评估了 TOF 和 RIR 对新诊断前列腺癌患者的标准化摄取值(最大和峰值 SUV [SUVmax 和 SUVpeak])及其代谢肿瘤体积相关性和 18F- 氟胆碱 PET/MRI 可视图像质量的影响。为 14 名患者注射了 3 MBq/kg 的 18F-氟胆碱,并进行了 30 分钟的动态扫描。正电子发射断层扫描图像分为早期和晚期时间点(1-6 分钟总和和 7-30 分钟总和)。记录 PET 显像病灶的不同 SUV 值,并使用 50% 等值线和 2.5 的 SUV 临界值估算代谢肿瘤体积。图像质量通过视觉敏锐度评分(VAS)进行评估。我们发现,加入 TOF 或 RIR 会增加病灶 SUV。TOF重建并未改善病灶与背景的比例,而RIR则显著改善了病灶与背景的比例(P < .05)。RIR图像比TOF图像、RIR图像比非TOF图像和TOF图像比非TOF图像的不同VAS值都明显更高(P < .05)。总之,我们的数据表明,在有条件的情况下,TOF 或 RIR 应被纳入目前的方案中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With <sup>18</sup>F-Fluorocholine Dual Time Point PET/MRI.

Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With <sup>18</sup>F-Fluorocholine Dual Time Point PET/MRI.

Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With <sup>18</sup>F-Fluorocholine Dual Time Point PET/MRI.

Effect of Time-of-Flight and Regularized Reconstructions on Quantitative Measurements and Qualitative Assessments in Newly Diagnosed Prostate Cancer With 18F-Fluorocholine Dual Time Point PET/MRI.

Recent technical advances in positron emission tomography/magnetic resonance imaging (PET/MRI) technology allow much improved time-of-flight (TOF) and regularized iterative PET reconstruction regularized iterative reconstruction (RIR) algorithms. We evaluated the effect of TOF and RIR on standardized uptake values (maximum and peak SUV [SUVmax and SUVpeak]) and their metabolic tumor volume dependencies and visual image quality for 18F-fluorocholine PET/MRI in patients with newly diagnosed prostate cancer. Fourteen patients were administered with 3 MBq/kg of 18F-fluorocholine and scanned dynamically for 30 minutes. Positron emission tomography images were divided to early and late time points (1-6 minutes summed and 7-30 minutes summed). The values of the different SUVs were documented for dominant PET-avid lesions, and metabolic tumor volume was estimated using a 50% isocontour and SUV threshold of 2.5. Image quality was assessed via visual acuity scoring (VAS). We found that incorporation of TOF or RIR increased lesion SUVs. The lesion to background ratio was not improved by TOF reconstruction, while RIR improved the lesion to background ratio significantly ( P < .05). The values of the different VAS were all significantly higher ( P < .05) for RIR images over TOF, RIR over non-TOF, and TOF over non-TOF. In conclusion, our data indicate that TOF or RIR should be incorporated into current protocols when available.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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