肿瘤细胞外囊泡的生物分布、摄取及影响。

Q3 Medicine
Journal of Circulating Biomarkers Pub Date : 2015-03-25 eCollection Date: 2015-01-01 DOI:10.5772/60522
Lilite Sadovska, Cristina Bajo Santos, Zane Kalniņa, Aija Linē
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引用次数: 24

摘要

近年来,细胞外囊泡(EVs)已成为细胞间通讯的重要介质。它们由各种正常和癌细胞类型释放到细胞外空间,并且在所有人体体液中都有发现。癌症源性ev携带脂质、蛋白质、mrna、非编码和结构rna,甚至染色体外DNA,可被受体细胞吸收并引发多种生理和病理反应。越来越多的证据表明,癌症衍生的ev介导癌细胞之间的旁分泌信号。这导致了侵袭性、增殖率和化疗耐药性的增加,以及癌症干细胞表型的获得。这会刺激血管生成,并将正常基质细胞重新编程为促进癌症的细胞类型。此外,癌症来源的ev有助于形成转移前生态位和调节抗肿瘤免疫反应。然而,由于这些数据大多是通过体外研究获得的,因此尚不完全清楚这些影响中哪些在体内重现。在当前的综述中,我们总结了评估体内肿瘤源性ev的组织分布、运输、清除和吸收的研究,并讨论了它们对局部和系统的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Biodistribution, Uptake and Effects Caused by Cancer-Derived Extracellular Vesicles.

Biodistribution, Uptake and Effects Caused by Cancer-Derived Extracellular Vesicles.

Biodistribution, Uptake and Effects Caused by Cancer-Derived Extracellular Vesicles.

Extracellular vesicles (EVs) have recently emerged as important mediators of intercellular communication. They are released in the extracellular space by a variety of normal and cancerous cell types and have been found in all human body fluids. Cancer-derived EVs have been shown to carry lipids, proteins, mRNAs, non-coding and structural RNAs and even extra-chromosomal DNA, which can be taken up by recipient cells and trigger diverse physiological and pathological responses. An increasing body of evidence suggests that cancer-derived EVs mediate paracrine signalling between cancer cells. This leads to the increased invasiveness, proliferation rate and chemoresistance, as well as the acquisition of the cancer stem cell phenotype. This stimulates angiogenesis and the reprogramming of normal stromal cells into cancer-promoting cell types. Furthermore, cancer-derived EVs contribute to the formation of the pre-metastatic niche and modulation of anti-tumour immune response. However, as most of these data are obtained by in vitro studies, it is not entirely clear which of these effects are recapitulated in vivo. In the current review, we summarize studies that assess the tissue distribution, trafficking, clearance and uptake of cancer-derived EVs in vivo and discuss the impact they have, both locally and systemically.

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来源期刊
Journal of Circulating Biomarkers
Journal of Circulating Biomarkers Medicine-Biochemistry (medical)
CiteScore
3.20
自引率
0.00%
发文量
9
审稿时长
8 weeks
期刊介绍: Journal of Circulating Biomarkers is an international, peer-reviewed, open access scientific journal focusing on all aspects of the rapidly growing field of circulating blood-based biomarkers and diagnostics using circulating protein and lipid markers, circulating tumor cells (CTC), circulating cell-free DNA (cfDNA) and extracellular vesicles, including exosomes, microvesicles, microparticles, ectosomes and apoptotic bodies. The journal publishes high-impact articles that deal with all fields related to circulating biomarkers and diagnostics, ranging from basic science to translational and clinical applications. Papers from a wide variety of disciplines are welcome; interdisciplinary studies are especially suitable for this journal. Included within the scope are a broad array of specialties including (but not limited to) cancer, immunology, neurology, metabolic diseases, cardiovascular medicine, regenerative medicine, nosology, physiology, pathology, technological applications in diagnostics, therapeutics, vaccine, drug delivery, regenerative medicine, drug development and clinical trials. The journal also hosts reviews, perspectives and news on specific topics.
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