Sarah Moussa, Günther Grabner, Josef Ruckhofer, Marie Dietrich, Herbert Reitsamer
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Background: Keratoconus is characterized as a bilateral, progressive, non-inflammatory thinning of the cornea resulting in blurred vision due to irregular astigmatism. Keratoconus has a multifactorial etiology, with multiple genetic and environmental components contributing to the disease pathophysiology. Several genomic loci and genes have been identified that highlight the complex molecular etiology of this disease.
Conclusion: The review focuses on current knowledge of these genetic risk factors associated with keratoconus.
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