{"title":"测量真核生物转录起始的动力学:挑战，见解和机遇。","authors":"Zhengjian Zhang, Robert Tjian","doi":"10.1080/21541264.2017.1363017","DOIUrl":null,"url":null,"abstract":"<p><p>Transcription of protein-encoding genes in eukaryotic cells is a dynamically coordinated process. Many of the key transcription regulators contain functionally essential intrinsically disordered regions (IDRs), the dynamic nature of which creates extra challenges to traditional biochemical analyses. Recent advances in single-molecule fluorescence imaging technology have enabled direct visualization of these rapid, complex and dynamic molecular interactions in real time.</p>","PeriodicalId":47009,"journal":{"name":"Transcription-Austin","volume":"9 3","pages":"159-165"},"PeriodicalIF":3.6000,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/21541264.2017.1363017","citationCount":"13","resultStr":"{\"title\":\"Measuring dynamics of eukaryotic transcription initiation: Challenges, insights and opportunities.\",\"authors\":\"Zhengjian Zhang, Robert Tjian\",\"doi\":\"10.1080/21541264.2017.1363017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Transcription of protein-encoding genes in eukaryotic cells is a dynamically coordinated process. Many of the key transcription regulators contain functionally essential intrinsically disordered regions (IDRs), the dynamic nature of which creates extra challenges to traditional biochemical analyses. Recent advances in single-molecule fluorescence imaging technology have enabled direct visualization of these rapid, complex and dynamic molecular interactions in real time.</p>\",\"PeriodicalId\":47009,\"journal\":{\"name\":\"Transcription-Austin\",\"volume\":\"9 3\",\"pages\":\"159-165\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2018-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/21541264.2017.1363017\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transcription-Austin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/21541264.2017.1363017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/10/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transcription-Austin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/21541264.2017.1363017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/10/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Measuring dynamics of eukaryotic transcription initiation: Challenges, insights and opportunities.
Transcription of protein-encoding genes in eukaryotic cells is a dynamically coordinated process. Many of the key transcription regulators contain functionally essential intrinsically disordered regions (IDRs), the dynamic nature of which creates extra challenges to traditional biochemical analyses. Recent advances in single-molecule fluorescence imaging technology have enabled direct visualization of these rapid, complex and dynamic molecular interactions in real time.
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