中毒性表皮坏死松解:回顾过去和现在的治疗方法

Q1 Medicine

Skin therapy letter Pub Date : 2022-09-01

Neha Singh, Mariana Phillips

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引用次数: 0

摘要

中毒性表皮坏死松解(TEN)是一种免疫介导的严重皮肤药物不良反应，其特征是表皮脱离影响大于30%的体表面积。TEN的死亡率超过20%，通常由感染和呼吸系统损伤引起。停用致病性药物、支持治疗和辅助治疗可改善预后。在过去的十年中，随机对照试验和荟萃分析支持环孢素、肿瘤坏死因子α抑制剂以及静脉注射免疫球蛋白和皮质类固醇联合治疗的作用。本文综述了成人TEN患者的医疗管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Toxic Epidermal Necrolysis: A Review of Past and Present Therapeutic Approaches

Toxic epidermal necrolysis (TEN) is an immune mediated, severe cutaneous adverse drug reaction characterized by epidermal detachment affecting greater than 30% body surface area. The mortality rate of TEN exceeds 20% and is usually caused by infection and respiratory compromise. Withdrawal of the causative drug, supportive care, and adjuvant therapy improve prognosis. Over the past decade, randomized controlled trials and meta-analyses have supported a role for cyclosporine, tumor necrosis factor alpha inhibitors, and combination therapy with intravenous immune globulin and corticosteroids. This review summarizes the medical management of TEN in adult patients.

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来源期刊

Skin therapy letter Medicine-Medicine (all)

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： The premier international journal on the latest advances, techniques and practice in conservation and restoration from around the world.