足月出生时胎龄小的成年人乳头周围视网膜神经纤维层比对照组薄。

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2022-11-25 eCollection Date: 2022-01-01 DOI:10.2147/EB.S383231
Achim Fieß, Marilena Brandt, Eva Mildenberger, Michael Siegfried Urschitz, Felix Mathias Wagner, Stephanie Desiree Grabitz, Esther Maria Hoffmann, Norbert Pfeiffer, Alexander Konrad Schuster
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引用次数: 2

摘要

目的:产前生长限制与儿童神经发育受损有关。本研究探讨了足月出生的成人小胎龄(SGA)对乳头周围视网膜神经纤维层(pRNFL)厚度的影响。方法:回顾性队列研究,对1969年至2002年间足月出生(胎龄≥37周)的参与者进行前瞻性眼科检查。所有参与者均接受光谱域光学相干断层扫描检查,并根据出生体重与胎龄的相关性分为中度(出生体重(BW)第3至90至97百分位)和重度(>97百分位)胎龄(LGA)成人(18至52岁)。结果:共纳入285例足月出生个体(年龄29.9±9.4岁,女性151例)547只眼。多变量回归分析显示,严重SGA患者整体pRNFL厚度较低之间有很强的相关性(B=-8.99 [95%-CI: -12.68;-5.30µm;结论:我们的研究结果表明,胎儿生长受限会影响视神经头的神经组织发育,尤其是足月出生时严重SGA的个体。这表明胎儿生长受限可能会对神经组织的发育造成干扰,这种情况会持续到成年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Adults Born Small for Gestational Age at Term Have Thinner Peripapillary Retinal Nerve Fiber Layers Than Controls.

Adults Born Small for Gestational Age at Term Have Thinner Peripapillary Retinal Nerve Fiber Layers Than Controls.

Adults Born Small for Gestational Age at Term Have Thinner Peripapillary Retinal Nerve Fiber Layers Than Controls.

Purpose: Prenatal growth restriction is associated with impaired neurodevelopment in childhood. This study investigated the effects of being born small for gestational age (SGA) on peripapillary retinal nerve fiber layer (pRNFL) thickness in adults born at term.

Methods: A retrospective cohort study was conducted with a prospective ophthalmologic examination of participants born at full-term (gestational age ≥37 weeks) between 1969 and 2002. All participants were examined with spectral-domain optical coherence tomography and grouped according to their birth weight in correlation to gestational age as former moderate (birth weight (BW) percentile 3rd to <10th) and severe SGA (<3rd percentile), normal (10th-90th percentile, AGA), and moderately (>90th to 97th percentile) and severely (>97th percentile) large for gestational age (LGA) adults (18 to 52 years).

Results: Overall, 547 eyes of 285 individuals (age 29.9±9.4 years, 151 females) born at term were included. Multivariable regression analyses revealed a strong association between a lower global pRNFL thickness in the severe SGA (B=-8.99 [95%-CI: -12.68; -5.30] µm; p<0.001) and in the moderate SGA groups (B=-6.40 [95%-CI: -10.29; -2.50] µm; p=0.001) compared to the reference AGA group.

Conclusion: Our results indicate that restricted fetal growth affects neurologic tissue development of the optic nerve head, particularly in individuals born severely SGA at term. This indicates that fetal growth restriction may exert disturbances in the development of neurologic tissue, which persists in adulthood.

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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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