双能量 SPECT 和用于淀粉样变性成像的多肽 p5+14 的开发。

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Jonathan S Wall, Stephen J Kennel, Emily B Martin
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引用次数: 0

摘要

淀粉样变性与多种罕见疾病相关,其特征是细胞外蛋白质纤维沉积在腹腔器官和外周神经,导致功能障碍和严重的发病率。由于缺乏检测全身淀粉样蛋白负荷的非侵入性定量方法,妨碍了对全身性淀粉样变性患者进行有效的临床评估和管理。我们使用了一系列检测方法,包括双能 SPECT 成像和比较效果研究,以支持将合成多基肽 p5+14 转化为新型放射性示踪剂,通过分子成像来观察淀粉样变性。这些数据为该试剂的正电子发射断层扫描/计算机断层扫描成像一期试验提供了支持,该试剂用碘-124标记,适用于各种形式的全身性淀粉样变性患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

Amyloidosis is associated with a number of rare diseases and is characterized by the deposition, in abdominothoracic organs and peripheral nerves, of extracellular protein fibrils, which leads to dysfunction and severe morbidity. Effective clinical evaluation and management of patients with systemic amyloidosis are hampered by the lack of a noninvasive, quantitative method for detecting whole-body amyloid load. We have used a battery of assays including dual-energy SPECT imaging and comparative effectiveness studies in support of translation of a synthetic polybasic peptide, p5+14, as a novel radiotracer for visualization of amyloidosis by molecular imaging. These data provide support for a phase 1 positron emission tomography/computed tomography imaging trial of this reagent, labeled with iodine-124, in patients with all forms of systemic amyloidosis.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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