使用[18F]-NaF PET-MRI成像骨关节炎中骨-软骨相互作用。

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Dragana Savic, Valentina Pedoia, Youngho Seo, Jaewon Yang, Matt Bucknor, Benjamin L Franc, Sharmila Majumdar
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引用次数: 46

摘要

目的:同步正电子发射断层扫描-磁共振成像(PET-MRI)是一种新兴的技术,在不增加扫描时间的情况下提供解剖和功能图像。与传统的PET/计算机断层扫描成像相比,它还使患者暴露在更少的辐射下,并提供更好的解剖图像,因为MRI提供了更好的软组织特征。利用PET-MRI,我们旨在研究膝关节骨性关节炎(OA)中软骨组成和骨功能之间的相互作用。方法:本文采用[18F]-氟化钠(NaF) PET数据研究骨转换和骨重塑。定量mr衍生的T1ρ松弛时间表征生化软骨退变。16名有膝关节OA早期症状的参与者在PET-MR图像采集开始时接受静脉注射[18F]-NaF。确定了感兴趣的区域,动态PET数据的动力学分析提供了[18F]-NaF在骨中的摄取速率(Ki)和标准化摄取值(标准化摄取值)。采用基于图集的配准技术自动分割软骨,获得形态学MR图像和定量的基于体素的软骨T1ρ图。使用逐体素统计参数映射来研究骨和软骨之间的关系。结果:软骨T1ρ升高,表明退行性改变,与相邻骨的周转量增加有关,而与非相邻骨室的周转量减少有关。在没有软骨形态病变的情况下,疼痛和骨摄取增加之间存在关联,但在有软骨病变的情况下,这种关系是相反的。结论:本研究首次在人体研究中同时使用[18F]-NaF PET-MR显示膝关节OA中软骨和骨的显著相互作用。这些观察结果强调了OA患者整个膝关节复杂的生物力学和生化相互作用,这可能有助于评估OA治疗的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Imaging Bone-Cartilage Interactions in Osteoarthritis Using [<sup>18</sup>F]-NaF PET-MRI.

Imaging Bone-Cartilage Interactions in Osteoarthritis Using [<sup>18</sup>F]-NaF PET-MRI.

Imaging Bone-Cartilage Interactions in Osteoarthritis Using [<sup>18</sup>F]-NaF PET-MRI.

Imaging Bone-Cartilage Interactions in Osteoarthritis Using [18F]-NaF PET-MRI.

Purpose: Simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI) is an emerging technology providing both anatomical and functional images without increasing the scan time. Compared to the traditional PET/computed tomography imaging, it also exposes the patient to significantly less radiation and provides better anatomical images as MRI provides superior soft tissue characterization. Using PET-MRI, we aim to study interactions between cartilage composition and bone function simultaneously, in knee osteoarthritis (OA).

Procedures: In this article, bone turnover and remodeling was studied using [18F]-sodium fluoride (NaF) PET data. Quantitative MR-derived T relaxation times characterized the biochemical cartilage degeneration. Sixteen participants with early signs of OA of the knee received intravenous injections of [18F]-NaF at the onset of PET-MR image acquisition. Regions of interest were identified, and kinetic analysis of dynamic PET data provided the rate of uptake ( Ki) and the normalized uptake (standardized uptake value) of [18F]-NaF in the bone. Morphological MR images and quantitative voxel-based T maps of cartilage were obtained using an atlas-based registration technique to segment cartilage automatically. Voxel-by-voxel statistical parameter mapping was used to investigate the relationship between bone and cartilage.

Results: Increases in cartilage T, indicating degenerative changes, were associated with increased turnover in the adjoining bone but reduced turnover in the nonadjoining compartments. Associations between pain and increased bone uptake were seen in the absence of morphological lesions in cartilage, but the relationship was reversed in the presence of incident cartilage lesions.

Conclusion: This study shows significant cartilage and bone interactions in OA of the knee joint using simultaneous [18F]-NaF PET-MR, the first in human study. These observations highlight the complex biomechanical and biochemical interactions in the whole knee joint in OA, which potentially could help assess therapeutic targets in treating OA.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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